Publication Date:
1984-03-23
Description:
An antiserum to the insulin receptor mimicked insulin's acute actions on glucose transport, phosphorylation of integral membrane proteins, and internalization of the insulin receptor in isolated rat adipose cells. These insulinomimetic actions of the antiserum occurred without the equivalent increase in phosphorylation of the beta subunit of the insulin receptor observed with insulin. Thus, a role of receptor phosphorylation in acute insulin action is now questioned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, I A -- Hedo, J A -- New York, N.Y. -- Science. 1984 Mar 23;223(4642):1301-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6367041" target="_blank"〉PubMed〈/a〉
Keywords:
3-O-Methylglucose
;
Adipose Tissue/cytology
;
Animals
;
Biological Transport
;
Cell Membrane/metabolism
;
Immune Sera
;
Insulin/metabolism/*pharmacology
;
Membrane Proteins/metabolism
;
Methylglucosides/metabolism
;
Phosphorylation
;
Rats
;
Receptor, Insulin/immunology/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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