ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The cis-configurated isocephem 26 as well as isodethiaoxacephems 21 and 33 were synthesized (Schemes 4 and 5). The key step involves chlorination of the corresponding carbanions of 23, 18, and 31 with CF3SO2Cl followed by internal alkylation. β-Lactams 3, 21, 26, and 33 were found to possess biological activity against several pathogenic microorganisms in vitro. Electronic activation of the lactam moiety in isodethiaoxacephem 33 remarkably enhanced its biological activity.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19960790323
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