Publication Date:
2016-02-23
Description:
Four new ent -pimarane diterpenes were isolated from the ethanol extract of Aralia dumetorum , together with three known compounds involving ent -pimar-8 (14),15-dien-19-oic acid (5), ent -pimar - 8 (14), 15-dien-19-ol (6), ent -kaur-16-en-19-oic acid (7). By detailed analyses of the MS, IR, and NMR data, the structures of four new diterpenes were characterized as (5 β ,9 β ,10 α ,13 α )-Pimara-6,8(14),15-trien-18-oic acid (1), (5 β ,7 β ,9 β ,10 α ,13 α )-7-methoxypimara-8(14),15-dien-18-oic acid (2), (5 β ,9 β ,10 α ,13 α ,14 β )-14-methoxypimara-7,15-dien-18-oic acid (3) and (5 β ,10 α ,13 α ,14 α )-14-hydroxypimara-7,9(11),15-trien-18-oic acid (4). The cytotoxic activities of compounds 1-7 were assayed in vitro through MTT method. This article is protected by copyright. All rights reserved.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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