ISSN:
0006-3592
Keywords:
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Using continuous and fed-batch penicillin fermentation systems some important metabolic parameters have been determined for the purpose of achieving process improvement and better process control. The specific uptake rates determined under the optimal conditions are: 0.33 mmol hexose/g cell/hr, 1.6 mmol oxygen/g cell/hr, 2mg NH3-nitrogen/g cell/hr, 0.6 mg PO4-phosphorus/g cell/hr, 2.8 mg SO4-sulfur/g cell/hr, 1.8 mg phenyl acetic acid/g cell/hr. It was also found that during the production phase, or idiophase, the specific growth rate should be maintained at about 0.015 hr-1 in order to support the maximum penicillin productivity of the given strain. Based on the results of this study a significant process improvement has been achieved through proper control of the supply and demand of the important nutrients and oxygen.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bit.260220204
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