ISSN:
1573-4927
Keywords:
Rattus norvegicus
;
electrophoresis
;
carboxylesterases (EC 3.1.1.1)
;
polymorphism
;
strain distribution
;
linkage group V
;
esterase gene cluster 2
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract The segregation of rat esterases controlled by loci residing in linkage group V (LGV) has been studied in two backcross series, (LEW/Han × BN/Han)F1 × LEW/Han and (LEW/Han × LE/Han)F1 × LEW/Han. Es-14 (formerly Es-Si) was shown to be closely linked to Es-1. A new esterase locus, Es-15, was described which codes for a liver isozyme. The distribution pattern of three alleles at the Es-15 locus is presented for 52 independent inbred strains. Close linkage of Es-15 to Es-14 and to Es-1 was established, proposing the following gene order: [Es-2, Es-10]—[ES-1, ES-14, ES-15]. The esterase loci on LGV are thus separated into two gene clusters, cluster 1 and cluster 2. These conclusions are supported by the strain distribution patterns of the two RI strain series, LXB and DXE.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00498953
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