Publication Date:
2014-05-15
Description:
Article E3 ligases that attach ubiquitin to proteins destined for proteasomal degradation are regulated by neddylation. In this study, Xie et al . show that the HECT ligase Smurf1, which is a ubiquitin ligase, is also neddylated, and this post-translational modification enhances its ligase activity. Nature Communications doi: 10.1038/ncomms4733 Authors: Ping Xie, Minghua Zhang, Shan He, Kefeng Lu, Yuhan Chen, Guichun Xing, Yiming Lu, Ping Liu, Yang Li, Shaoxia Wang, Nan Chai, Jiawei Wu, Haiteng Deng, Hong-Rui Wang, Yu Cao, Fei Zhao, Yu Cui, Jian Wang, Fuchu He, Lingqiang Zhang
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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