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  • 1
    Electronic Resource
    Electronic Resource
    Video analysis of DNA sequence homologs (1992)
    s.l. : American Chemical Society
    Analytical chemistry 64 (1992), S. 2678-2681 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00046a005
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  • 2
    Electronic Resource
    Electronic Resource
    Linkage disequilibrium of HLA-SB1 with the HLA-A1, B8, DR3, SCO1 and of HLA-SB4 with the HLA-A26, Bw38, Dw10, DR4, SC21 extended haplotypes (1984)
    Springer
    Immunogenetics 20 (1984), S. 623-631 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Homozygous typing cells from 13 normal HLA-A1, B8, Dw3, DR3 and five normal HLA-A26, Bw38, Dw10, DR4 individuals were typed for the following markers: HLA-SB, MB, MT; complement proteins BF, C2, C4A, C4B; and GLO. Ninety-one percent of A1, B8, Dw3, DR3 homozygous individuals (HI) tested were homozygous for BF * S, C2 * C, C4A * QO, and C4B *1 (SCO1 complotype), which indicates that the SCO1 complotype is in linkage disequilibrium with the A1, B8, DR3 haplotype in randomly selected normal populations. Sixty-seven percent of HLA-A1, B8, Dw3, DR3, SCO1 positive HI also expressed SB1; since the frequency of SB 1 in random Caucasian populations is 11.2%, this finding indicates that SB1 is in linkage disequilibrium with the A1, B8, DR3, SCO1 extended haplotype. All HI with the A26, Bw38, Dw10, DR4 haplotype were homozygous for both SC21 and SB4, suggesting that SC21 and SB4 should be included in the A26, Bw38, Dw10, DR4 extended haplotype. On the other hand, neither of the GLO markers were found in association with either haplotype. The results of this study indicate that HLA-SB is included in some extended haplotypes and may be important in these markers for diseases such as insulin-dependent diabetes mellitus. This study also demonstrated an apparent influence of HLA-SB on primary mixed lymphocyte culture (MLC) responses. The mean relative response of primary MLCs between individuals matched for HLA-A, B, D, DR, MB and MT but not SB was 40% of that for the MLCs with mismatched HLA-D, significantly higher than the MLCs matched for all HLA and complotypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430320
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization of human T-lymphocyte clones (TLCs) specific for HLA-region gene products (1982)
    Springer
    Immunogenetics 16 (1982), S. 117-133 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Clones of lymphocytes, primed in vitro to HLA-DR1; Dw1, were tested for allospecific proliferation on a panel of thirty-one HLA-phenotyped stimulating cells. No clone was restimulated exclusively by cells sharing the DR1; Dw1 priming antigens and most clones were restimulated by subsets of cells bearing DR1; Dw1. Generally, positive responses were at least 20-fold higher than autologous negative controls. Peak proliferative responses occurred around 72 h and varied, depending on the stimulating cell as well as the responding clone. Selected clones were induced to proliferate only by cells incapable of forming rosettes with sheep erythrocytes. Specific proliferation by TLCs was blocked by monoclonal DR-specific antibodies, but not by monoclonal anti-Thy 1.2. Genetic studies demonstrated that TLCs detected some cell-surface determinants that are encoded by genes in linkage disequilibrium with HLA and others that may not be linked to the human major histocompatibility complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364399
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  • 4
    Electronic Resource
    Electronic Resource
    Human allospecific TLCs generated against HLA antigens associated with DR1 through DRw8 (1986)
    Springer
    Immunogenetics 23 (1986), S. 368-378 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract To study the fine specificity of the HLA-D region, a panel of human T-lymphocyte clones (TLCs) was generated against alloantigens associated with HLA-DR1 through DRw8. HLA-DR-homozygous peripheral blood lymphocytes (PBLs) were stimulated with DR-heterozygous PBLs in primary mixed lymphocyte cultures for 4 days. Blasts were cloned by limiting dilution at 0.3 cells/well in the presence of 20% T-cell growth factor and irradiated stimulator cells. Viable clones were subsequently tested in proliferation assays against the original stimulator and a limited panel of stimulators bearing relevant DR specificities. Initial primings produced approximately 800 clones; some recognized DR-associated antigens, 70 recognized only their original stimulator, and approximately 50% were nonresponsive. Analysis on extended stimulator panels revealed alloantigenic complexity within similar DR-associated antigens as recognized by TLCs. The data are consistent with evidence that extreme heterogeneity exists within the HLA-D region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00372669
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  • 5
    Electronic Resource
    Electronic Resource
    Human helper T-cell clones that recognize different influenza hemagglutinin determinants are restricted by different HLA-D region epitopes (1984)
    Springer
    Immunogenetics 19 (1984), S. 409-423 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Human T-lymphocyte clones (TLCs) were generated against the hemagglutinin (HA) of A/Texas/1/77 influenza virus by limiting dilution. TLCs were then screened for antigen specificity on chemically synthesized peptides representing the HA1 molecule. It has been hypothesized that different T cells that recognize the identical antigenic determinant are controlled by (restricted by) the same class II epitope. Two TLCs, HA1.4 and HA1.7, both recognized the same HA peptide and in proliferation studies exhibited identical restriction patterns. Two other clones, HA 1.9 and HA 2.43, recognized different HA determinants and also had distinct restriction patterns. Proliferation inhibition studies with monoclonal antibodies against human class II molecules demonstrated three unique patterns of blocking with the clones, suggesting that clones may be restricted to a unique class II epitope depending on the HA determinant recognized. These data can be interpreted as supporting the argument that human immune responses to influenza hemagglutinin are under Ir gene control exerted at the level of the viral antigenic determinant recognized in association with particular D-region restricting elements. The determinant selection and clonal deletion theories are compared for their capacity to best explain these findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364644
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  • 6
    Electronic Resource
    Electronic Resource
    Human allospecific TLCs generated against HLA antigens associated with DRl through DRw8 (1988)
    Springer
    Immunogenetics 27 (1988), S. 31-39 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have studied the complexity and fine specificity of the HLA-D region using a panel of T lymphocyte clones generated against alloantigens associated with HLA-DR1 through DRw8. After extensive testing in population studies, 89 clones were tested in proliferation assays with 14 families. Segregation patterns were analyzed for haplotype associations by calculating sequential lod scores to test the likelihood that genes encoding epitopes detected by TLCs were linked to HLA genes. Four general categories were identified: (1) clonal responses that segregated with the same HLA-D region haplotype in all informative pedigrees; (2) clonal responses that segregated with HLA in all pedigrees but not always with the same haplotype; (3) clonal responses that segregated with HLA in some families but failed to segregate in others or produced equivocal results; (4) clonal responses that did not segregate with HLA haplotypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404441
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  • 7
    Electronic Resource
    Electronic Resource
    Human allospecific TLCs generated against HLA antigens associated with DR1 through DRw8 (1986)
    Springer
    Immunogenetics 24 (1986), S. 286-297 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Serologic, cellular, and molecular evidence supports the concept of extreme complexity within the HLA-D region. To study the complexity and fine specificity of the HLA-D region at the level of T -cell recognition, a panel of T-cell clones was generated against alloantigens associated with HLA-DRI through -DRw8. After initial screening of more than 800 clones, 89 representative lines were selected for extensive testing against 204 unrelated stimulator cells. Clone-by-clone correlation analyses were performed to test whether any clones recognized similar or identical epitopes. In addition, clonal reactivity patterns were correlated with known HLA specificities. Twelve clusters of clones were identified with similar reactivity patterns using clone-by-clone correlation analysis. Some groups were significantly correlated with specificities associated with various D-region haplotypes; others had no significant correlation with any defined D-region specificity. Five general types of clones obtained in our study can be categorized as follows: (1) Those recognizing epitopes clearly demonstrating a primary association with the classically defined D-region molecules against which the clones were primed. (2) Clones recognizing epitopes associated with one of the priming antigens and also with another unrelated D-region specificity. (3) Clones detecting epitopes which showed significant correlation with D-region molecules totally different from those against which they were originally primed. (4) Clones with limited reactivity in population studies and no correlation with defined D-region molecules. (5) Clones recognizing class I-associated epitopes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395533
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  • 8
    Electronic Resource
    Electronic Resource
    Diversity associated with the second expressed H L A - D R B locus in the human population (1997)
    Springer
    Immunogenetics 46 (1997), S. 104-110 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Although diversity within the HLA-DRB region is predominantly focused in the DRB1 gene, the second expressed DRB loci, DRB3, DRB4, and DRB5, also exhibit variation. Within DRB1 * 15 or DRB1 * 16 haplotypes, four new variants were identified: 1) two new DRB5 alleles, DRB5 * 0104 and DRB5 * 0204, 2) a haplotype carrying a DRB1 * 15 or * 16 allele without the usual accompanying DRB5 allele, and 3) a haplotype carrying a DRB5* 0101 allele without a DRB1 * 15 or * 16 allele. The evolutionary origins of these haplotypes were postulated based on their associations with the DRB6 pseudogene. Within HLA haplotypes which carry DRB3, a new DRB3 * 0205 allele and one unusual DRB3 association were identified. Finally, two new null DRB4 alleles are described: DRB4 * 0201N, which exhibits a deletion in the second exon, and a second allele, DRB4 * null, which lacks the second exon completely. Gene conversion-like events and variation in the number of functional genes through reciprocal recombination and inactivation contribute to the diversity observed in the second expressed HLA-DRB loci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050248
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  • 9
    Electronic Resource
    Electronic Resource
    SB -restricted presentation of influenza and herpes simplex virus antigens to human T-Iymphocyte clones (1983)
    [s.l.] : Nature Publishing Group
    Nature 301 (1983), S. 716-718 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Peripheral blood lymphocytes (PBLs) from donor 144 (HLA-Al; B8; DR1, 3; Dwl, 3; SB2, 4) were primed in vitro with the strain A influenza virus A/Texas/I-77/x-49. Lymphoblasts were enriched on a Percoll gradient and cloned by limiting dilution in the presence of T-cell growth factor, antigen and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/301716a0
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  • 10
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    Human allospecific TLCs generated against HLA antigens associated with DR1 through DRw8 (1986)
    Springer
    Details
    Publication Date: 1986-06-01
    Print ISSN: 0093-7711
    Electronic ISSN: 1432-1211
    Topics: Biology , Medicine
    Published by Springer
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