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  • 1
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    Use of cyclotron-produced fast neutrons in activation analysis (1985)
    Springer
    Details
    Publication Date: 1985-06-01
    Print ISSN: 0236-5731
    Electronic ISSN: 1588-2780
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Published by Springer
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    PAPER CURRENT
  • 2
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    Delayed expression of hpS2 and prolonged expression of CIP1/WAF1/SDI1 in human tumour cells irradiated with X-rays, fission neutrons or 1 GeV/nucleon Fe ions (1999)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: PURPOSE: Differences in gene expression underlie the phenotypic differences between irradiated and unirradiated cells. The goal was to identify late-transcribed genes following irradiations differing in quality, and to determine the RBE of 1 GeV/n Fe ions. MATERIALS AND METHODS: Clonogenic assay was used to determine the RBE of Fe ions. Differential hybridization to cDNA target clones was used to detect differences in expression of corresponding genes in mRNA samples isolated from MCF7 cells irradiated with iso-survival doses of Fe ions (0 or 2.5 Gy) or fission neutrons (0 or 1.2 Gy) 7 days earlier. Northern analysis was used to confirm differential expression of cDNA-specific mRNA and to examine expression kinetics up to 2 weeks after irradiation. RESULTS: Fe ion RBE values were between 2.2 and 2.6 in the lines examined. Two of 17 differentially expressed cDNA clones were characterized. hpS2 mRNA was elevated from 1 to 14 days after irradiation, whereas CIP1/WAF1/SDI1 remained elevated from 3 h to 14 days after irradiation. Induction of hpS2 mRNA by irradiation was independent of p53, whereas induction of CIP1/WAF1/SDI1 was observed only in wild-type p53 lines. CONCLUSIONS: A set of coordinately regulated genes, some of which are independent of p53, is associated with change in gene expression during the first 2 weeks post-irradiation.
    Keywords: Life Sciences (General)
    Type: International journal of radiation biology (ISSN 0955-3002); Volume 75; 5; 529-41
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    NASA TECHNICAL REPORTS
  • 3
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    Temperature uniformity in hyperthermal tumor therapy (1978)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Mouse mammary tumors heated by water bath or by microwave-induced hyperthermia exhibit a response that varies sharply with treatment temperature; therefore, uniform heating of the tumor is essential to quantitate the biological response as a function of temperature. C3H tumors implanted on the mouse flank were easily heated to uniformities within 0.1 C by using water baths. Cold spots up to 1 C below the desired treatment temperature were observed in the same tumors implanted on the hind leg. These cold spots were attributed to cooling by major blood vessels near the tumor. In this case temperature uniformity was achieved by the deposition of 2450 MHz microwave energy into the tumor volume by using parallel-opposed applicators.
    Keywords: AEROSPACE MEDICINE
    Type: NASA. Langley Res. Center Hyperthermia as an Antineoplastic Treatment Modality; p 27-32
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    A compact method for symbolic computation of the Riemann tensor (1969)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: Riemann tensor symbolic computation by compact method using differential forms, discussing advantages due to antisymmetry
    Keywords: COMPUTERS
    Type: ; ADEMIE DES SCIENCES
    Format: text
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    NASA TECHNICAL REPORTS
  • 5
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    Characterization of Treefoil Peptide Genes in Iron-Ion or X-Irradiated Human Cells (1999)
    In:  CASI
    Details
    Publication Date: 2019-08-16
    Description: The gastrointestinal (GI) tract is especially sensitive to ionizing radiation, probably because of its high rate of cell turn over. Most of the data in the literature concerns the histological/anatomical description of damage rather than functional studies. In fact, previous reports in humans have shown that, at doses of 2 Gy or more, functional abnormalities appear indicating that in radiation sensitive tissues the effects of radiation are not limited to cell death. GI functions are controlled in particular by GI peptides. One hypothesis is that ionizing radiation may modulate the synthesis and release of these peptides and consequently may contribute largely to abnormalities in GI function. However, no previous studies have been concerned with GI-specific gene expression in irradiated GI tissues. The family of human trefoil peptides comprises three members thus far, all of which are expressed in specific regions of the GI tract. In addition, two trefoil peptides, pS2 (TFFI) and HITF (TFF2) are expressed in breast tissue. Their exact function in GI and breast tissues is unclear but mucosal integrity, repair, mucin secretion and responsiveness to hormones have been shown. We recently isolated and characterized pS2 as a novel p53- and estrogen receptor-independent gene whose MRNA expression in several cells lines was found to be delayed 4 to 7 days after irradiation with X-rays, fission neutrons or 1 GeV/n Fe-ions. The aim of the present study was to determine whether pS2 and HITF have a similar induction kinetics in irradiated gastric and breast cell lines, and whether they have the phorbol ester (TPA) responsive element (TRE).
    Keywords: Aerospace Medicine
    Type: Proceedings of the First Biennial Space Biomedical Investigators' Workshop; 478-479
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    NASA TECHNICAL REPORTS
  • 6
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    Csa-19, a radiation-responsive human gene, identified by an unbiased two-gel cDNA library screening method in human cancer cells (1997)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: A novel polymerase chain reaction (PCR)-based method was used to identify candidate genes whose expression is altered in cancer cells by ionizing radiation. Transcriptional induction of randomly selected genes in control versus irradiated human HL60 cells was compared. Among several complementary DNA (cDNA) clones recovered by this approach, one cDNA clone (CL68-5) was downregulated in X-irradiated HL60 cells but unaffected by 12-O-tetradecanoyl phorbol-13-acetate, forskolin, or cyclosporin-A. DNA sequencing of the CL68-5 cDNA revealed 100% nucleotide sequence homology to the reported human Csa-19 gene. Northern blot analysis of RNA from control and irradiated cells revealed the expression of a single 0.7-kilobase (kb) messenger RNA (mRNA) transcript. This 0.7-kb Csa-19 mRNA transcript was also expressed in a variety of human adult and corresponding fetal normal tissues. Moreover, when the effect of X- or fission neutron-irradiation on Csa-19 mRNA was compared in cultured human cells differing in p53 gene status (p53-/- versus p53+/+), downregulation of Csa-19 by X-rays or fission neutrons was similar in p53-wild type and p53-null cell lines. Our results provide the first known example of a radiation-responsive gene in human cancer cells whose expression is not associated with p53, adenylate cyclase or protein kinase C.
    Keywords: Life Sciences (General)
    Type: Oncogene (ISSN 0950-9232); 14; 25; 3051-7
    Format: text
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    NASA TECHNICAL REPORTS
  • 7
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    BIGEL analysis of gene expression in HL60 cells exposed to X rays or 60 Hz magnetic fields (1998)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: We screened a panel of 1,920 randomly selected cDNAs to discover genes that are differentially expressed in HL60 cells exposed to 60 Hz magnetic fields (2 mT) or X rays (5 Gy) compared to unexposed cells. Identification of these clones was accomplished using our two-gel cDNA library screening method (BIGEL). Eighteen cDNAs differentially expressed in X-irradiated compared to control HL60 cells were recovered from a panel of 1,920 clones. Differential expression in experimental compared to control cells was confirmed independently by Northern blotting of paired total RNA samples hybridized to each of the 18 clone-specific cDNA probes. DNA sequencing revealed that 15 of the 18 cDNA clones produced matches with the database for genes related to cell growth, protein synthesis, energy metabolism, oxidative stress or apoptosis (including MYC, neuroleukin, copper zinc-dependent superoxide dismutase, TC4 RAS-like protein, peptide elongation factor 1alpha, BNIP3, GATA3, NF45, cytochrome c oxidase II and triosephosphate isomerase mRNAs). In contrast, BIGEL analysis of the same 1,920 cDNAs revealed no differences greater than 1.5-fold in expression levels in magnetic-field compared to sham-exposed cells. Magnetic-field-exposed and control samples were analyzed further for the presence of mRNA encoding X-ray-responsive genes by hybridization of the 18 specific cDNA probes to RNA from exposed and control HL60 cells. Our results suggest that differential gene expression is induced in approximately 1% of a random pool of cDNAs by ionizing radiation but not by 60 Hz magnetic fields under the present experimental conditions.
    Keywords: Life Sciences (General)
    Type: Radiation research (ISSN 0033-7587); 150; 6; 663-72
    Format: text
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    NASA TECHNICAL REPORTS
  • 8
    Electronic Resource
    Electronic Resource
    Use of cyclotron-produced fast neutrons in activation analysis (1985)
    Springer
    Journal of radioanalytical and nuclear chemistry 94 (1985), S. 391-397 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The determination of 15 elements: Pb, Sr, Ba, ti, Ca, Sc, Cs, Zr, Rb, Cr, Se, Ni, Y, Co and Zn was investigated by fast neutron activation analysis using 80 MeV deuterons on various environmental samples. Detection limits of these elements from interference-free spectra were calculated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02165700
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    Paper (German National Licenses)
    Fulltext
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