Publication Date:
2014-07-12
Description:
Article Antagonists of Smoothened, a class F GPCR involved in the hedgehog pathway, have been developed to treat some cancers. Here Wang et al. report structures of Smoothened in complex with antagonists and an agonist, and describe how mutations may result in resistance to anti-Smoothened treatment. Nature Communications doi: 10.1038/ncomms5355 Authors: Chong Wang, Huixian Wu, Tama Evron, Eyal Vardy, Gye Won Han, Xi-Ping Huang, Sandy J. Hufeisen, Thomas J. Mangano, Dan J. Urban, Vsevolod Katritch, Vadim Cherezov, Marc G. Caron, Bryan L. Roth, Raymond C. Stevens
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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