ISSN:
1573-0646
Keywords:
fludarabine monophosphate
;
drug induced pulmonary disease
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Fludarabine monophosphate (FAMP), the 2-fluoro, 5′phosphate derivative of 9-β-D-arabinofuranosyl adenine (ara-A), is a purine nucleoside antimetabolite presently undergoing clinical testing for the treatment of a variety of malignancies including lymphoproliferative disorders and acute leukemia. We report a case of diffuse interstitial pneumonitis during treatment of chronic lymphocytic leukemia with FAMP. This resolved quickly with high dose steroids, recurred with steroid withdrawal, and abated with further steroid therapy. To our knowledge, this is the first reported case of fludarabine monophosphate associated pulmonary toxicity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00203548
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