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  • 1
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    The development of a room temperature electron cyclotron resonance ion source (Lanzhou electron cyclotron resonance ion source No. 4) with evaporative cooling technology at Institute of Modern Physics (2015)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2015-04-07
    Description: LECR4 (Lanzhou electron cyclotron resonance ion source No. 4) has been successfully constructed at IMP and has also been connected with the Low Energy Beam Transport (LEBT) and Radio Frequency Quadrupole (RFQ) systems. These source magnet coils are cooled through evaporative cooling technology, which is the first attempt with an ECR ion source in the world. The maximum mirror field is 2.5 T (with iron plug) and the effective plasma chamber volume is 1.2 l. It was designed to be operated at 18 GHz and aimed to produce intense multiple charge state heavy ion beams for the linear injector project SSC-Linac at IMP. In February 2014, the first analyzed beam at 18 GHz was extracted. During about three months’ commissioning, some outstanding results have been achieved, such as 1.97 emA of O 6+ , 1.7 emA of Ar 8+ , 1.07 emA of Ar 9+ , and 118 euA of Bi 28+ . The source has also successfully delivered O 5+ and Ar 8+ ion beams for RFQ commissioning in April 2014. This paper will give a brief overview of the design of LECR4. Then, the latest results of this source at 18 GHz will be presented.
    Print ISSN: 0034-6748
    Electronic ISSN: 1089-7623
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Published by American Institute of Physics (AIP)
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  • 2
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    Unveiling atomic-scale features of inherent heterogeneity in metallic glass by molecular dynamics simulations (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-06-08
    Description: Author(s): Y. C. Hu, P. F. Guan, M. Z. Li, C. T. Liu, Y. Yang, H. Y. Bai, and W. H. Wang Heterogeneity is commonly believed to be intrinsic to metallic glasses (MGs). Nevertheless, how to distinguish and characterize the heterogeneity at the atomic level is still debated. Based on the extensive molecular dynamics simulations that combine isoconfigurational ensemble and atomic pinning me… [Phys. Rev. B 93, 214202] Published Mon Jun 06, 2016
    Keywords: Inhomogeneous, disordered, and partially ordered systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    Recombinant human kallistatin inhibits angiogenesis by blocking VEGF signaling pathway (2013)
    Wiley
    Details
    Publication Date: 2013-10-16
    Description: Kallistatin has been recognized as an endogenous angiogenic inhibitor. However, the underlying molecular mechanism remains poorly understood. Taking it into account that vascular endothelial growth factor (VEGF) has been implicated in all aspects of normal and pathological vasculogenesis and angiogenesis, in this study, we investigated whether VEGF signaling pathway was impacted by the anti-angiogenic effect of recombinant human kallistatin (rhKal). It has been found the rhKal inhibited proliferation as well as induced apoptosis of cultured human umbilical vein endothelial cells (HUVECs) in both concentration- and time-dependent manners. The rhKal also suppressed the VEGF-induced migration and tube formation of HUVECs. Furthermore, our data revealed that the rhKal suppressed the VEGF165-stimulated tyrosine phosphorylation of VEGFR-2 as well as its downstream signal molecular activation. The inhibition of receptor phosphorylation was correlated with a decrease in VEGF-triggered phosphorylation of angiogenesis signal molecules AKT and ERK, but not stress-related JNK. Taken together, these findings added the knowledge for us to understand the anti-angiogenic mechanism of kallistatin, which suggested that the rhKal could be worth as a candidate compound for further development for the purpose of anti-angiogenic therapies. J. Cell. Biochem. © 2013 Wiley Periodicals, Inc.
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley
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  • 4
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    Hybrid CuO/SnO2 nanocomposites: Towards cost-effective and high performance binder free lithium ion batteries anode materials (2014)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2014-10-11
    Description: Hybrid CuO/SnO 2 nanocomposites are synthesized by a facile thermal annealing method on Cu foils. Compared to pristine CuO and SnO 2 nanostructures, hybrid CuO/SnO 2 nanocomposites exhibit the enhanced electrochemical performances as the anode material of lithium ion batteries (LIBs) with high specific capacity and excellent rate capability. The binder free CuO/SnO 2 nanocomposites deliver a specific capacity of 718 mA h g −1 at a current density of 500 mA g −1 even after 200 cycles. The enhanced electrochemical performances are attributed to the synergistic effect between SnO 2 nanoparticles and CuO nanoarchitectures. Such hybrid CuO/SnO 2 nanocomposites could open up a new route for the development of next-generation high-performance and cost-effective binder free anode material of LIBs for mass production.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
    Published by American Institute of Physics (AIP)
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  • 5
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    Angle-Resolved Photoemission Spectroscopy of Tetragonal CuO: Evidence for Intralayer Coupling Between Cupratelike Sublattices (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-10-31
    Description: Author(s): S. Moser, L. Moreschini, H.-Y. Yang, D. Innocenti, F. Fuchs, N. H. Hansen, Y. J. Chang, K. S. Kim, A. L. Walter, A. Bostwick, E. Rotenberg, F. Mila, and M. Grioni We investigate by angle-resolved photoemission the electronic structure of in situ grown tetragonal CuO, a synthetic quasi-two-dimensional edge-sharing cuprate. We show that, in spite of the very different nature of the copper oxide layers, with twice as many Cu in the CuO layers of tetragonal CuO a... [Phys. Rev. Lett. 113, 187001] Published Thu Oct 30, 2014
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
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    The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells (2014)
    Oxford University Press
    Details
    Publication Date: 2014-12-17
    Description: The H19 lncRNA has been implicated in development and growth control and is associated with human genetic disorders and cancer. Acting as a molecular sponge, H19 inhibits microRNA (miRNA) let-7. Here we report that H19 is significantly decreased in muscle of human subjects with type-2 diabetes and insulin resistant rodents. This decrease leads to increased bioavailability of let-7, causing diminished expression of let-7 targets, which is recapitulated in vitro where H19 depletion results in impaired insulin signaling and decreased glucose uptake. Furthermore, acute hyperinsulinemia downregulates H19, a phenomenon that occurs through PI3K/AKT-dependent phosphorylation of the miRNA processing factor KSRP, which promotes biogenesis of let-7 and its mediated H19 destabilization. Our results reveal a previously undescribed double-negative feedback loop between sponge lncRNA and target miRNA that contributes to glucose regulation in muscle cells.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 7
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    Slab Control on the Northeastern Edge of the Mid‐Pacific LLSVP near Hawaii (2019)
    Wiley
    Details
    Publication Date: 2019
    Description: Abstract At the core‐mantle boundary, most observed ultra‐low velocity zones (ULVZ's) cluster along the edges of the large low shear velocity provinces (LLSVP's) and provide key information on the composition, dynamics and evolution of the lower mantle. However, their detailed structure near slab‐like structures beneath the mid‐Pacific remains particularly challenging because of the lack of station coverage. While most studies of ULVZ's concentrate on SKS‐complexity, here we report on the multi‐pathing of ScS which expands the sampling for ULVZ's. We find the strongest multi‐pathing along a ULVZ patch located just south of Hawaii and the far northeastern edge of the LLSVP, in a zone ~200 km in width and extending 600 km southward. The anomalous ScS travel times and distorted Sdiff waveforms further reveal patches interrupted by observed enhanced D" indicative of slab‐debris influence on the complexity of the northeastern boundary of the mid‐Pacific LLSVP.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 8
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    Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-04-10
    Description: Arsenic, an ancient drug used in traditional Chinese medicine, has attracted worldwide interest because it shows substantial anticancer activity in patients with acute promyelocytic leukemia (APL). Arsenic trioxide (As2O3) exerts its therapeutic effect by promoting degradation of an oncogenic protein that drives the growth of APL cells, PML-RARalpha (a fusion protein containing sequences from the PML zinc finger protein and retinoic acid receptor alpha). PML and PML-RARalpha degradation is triggered by their SUMOylation, but the mechanism by which As2O3 induces this posttranslational modification is unclear. Here we show that arsenic binds directly to cysteine residues in zinc fingers located within the RBCC domain of PML-RARalpha and PML. Arsenic binding induces PML oligomerization, which increases its interaction with the small ubiquitin-like protein modifier (SUMO)-conjugating enzyme UBC9, resulting in enhanced SUMOylation and degradation. The identification of PML as a direct target of As2O3 provides new insights into the drug's mechanism of action and its specificity for APL.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Xiao-Wei -- Yan, Xiao-Jing -- Zhou, Zi-Ren -- Yang, Fei-Fei -- Wu, Zi-Yu -- Sun, Hong-Bin -- Liang, Wen-Xue -- Song, Ai-Xin -- Lallemand-Breitenbach, Valerie -- Jeanne, Marion -- Zhang, Qun-Ye -- Yang, Huai-Yu -- Huang, Qiu-Hua -- Zhou, Guang-Biao -- Tong, Jian-Hua -- Zhang, Yan -- Wu, Ji-Hui -- Hu, Hong-Yu -- de The, Hugues -- Chen, Sai-Juan -- Chen, Zhu -- New York, N.Y. -- Science. 2010 Apr 9;328(5975):240-3. doi: 10.1126/science.1183424.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Road II, Shanghai 200025, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20378816" target="_blank"〉PubMed〈/a〉
    Keywords: Arsenic/*metabolism ; Arsenicals/*metabolism/*pharmacology ; Cell Line ; Humans ; Leukemia, Promyelocytic, Acute/drug therapy/genetics ; Mutant Proteins/chemistry/metabolism ; Mutation ; Nuclear Proteins/chemistry/genetics/*metabolism ; Oncogene Proteins, Fusion/chemistry/genetics/*metabolism ; Oxazines/metabolism ; Oxides/*metabolism/*pharmacology ; Protein Conformation ; Protein Multimerization ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Receptors, Retinoic Acid/metabolism ; Recombinant Fusion Proteins/chemistry/metabolism ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Transcription Factors/chemistry/genetics/*metabolism ; Tumor Suppressor Proteins/chemistry/genetics/*metabolism ; Ubiquitination ; Zinc Fingers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Extrinsic spin Hall effect from anisotropic Rashba spin-orbit coupling in graphene (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-02-12
    Description: Author(s): H.-Y. Yang, Chunli Huang, H. Ochoa, and M. A. Cazalilla The study of the spin Hall effect in graphene is an active field of research, but its experimental realization is proven to be difficult due to the inherently weak intrinsic spin-orbit interaction. Thus, one needs to rely on extrinsic spin-orbit scattering to be able to probe this effect in graphene. The authors of this paper have reported some progress in this direction. They predict that adatoms on graphene can induce an anisotropic Rashba spin-orbit coupling, and the degree of anisotropy has a noticeable effect on the energy dependence of the spin Hall angle. [Phys. Rev. B 93, 085418] Published Thu Feb 11, 2016
    Keywords: Surface physics, nanoscale physics, low-dimensional systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 10
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    Galaxies, Vol. 6, Pages 29: Unveiling the Origin of the Fermi Bubbles (2018)
    MDPI
    In: Galaxies
    Details
    Publication Date: 2018-03-06
    Description: Galaxies, Vol. 6, Pages 29: Unveiling the Origin of the Fermi Bubbles Galaxies doi: 10.3390/galaxies6010029 Authors: H.-Y. Yang Mateusz Ruszkowski Ellen Zweibel The Fermi bubbles, two giant structures above and below the Galactic center (GC), are among the most important discoveries of the Fermi Gamma-ray Space Telescope. Studying their physical origin has been providing valuable insights into cosmic-ray transport, the Galactic magnetic field, and past activity at the GC in the Milky Way galaxy. Despite their importance, the formation mechanism of the bubbles is still elusive. Over the past few years, there have been numerous efforts, both observational and theoretical, to uncover the nature of the bubbles. In this article, we present an overview of the current status of our understanding of the bubbles’ origin, and discuss possible future directions that will help to distinguish different scenarios of bubble formation.
    Electronic ISSN: 2075-4434
    Topics: Physics
    Published by MDPI
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