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  • 1
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    NSD1 mutations generate a genome-wide DNA methylation signature (2015)
    Springer Nature
    Details
    Publication Date: 2015-12-24
    Description: Article Sotos syndrome is an growth syndrome characterized by advanced growth in childhood, characteristic facial appearance and intellectual disability. Here the authors identify a genome-wide DNA methylation signature that accurately diagnoses Sotos Syndrome and distinguishes it from similar conditions. Nature Communications doi: 10.1038/ncomms10207 Authors: S. Choufani, C. Cytrynbaum, B. H. Y. Chung, A. L. Turinsky, D. Grafodatskaya, Y. A. Chen, A. S. A. Cohen, L. Dupuis, D. T. Butcher, M. T. Siu, H. M. Luk, I. F. M. Lo, S. T. S. Lam, O. Caluseriu, D. J. Stavropoulos, W. Reardon, R. Mendoza-Londono, M. Brudno, W. T. Gibson, D. Chitayat, R. Weksberg
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 2
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    Decay rates of a molecule in the vicinity of a spherical surface of an isotropic magnetodielectric material (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-10-10
    Description: Author(s): H. Y. Chung (鍾弘毅), P. T. Leung (梁培德), and D. P. Tsai (蔡定平) A comprehensive study is presented on the decay rates of excited molecules in the vicinity of a magnetodielectric material of spherical geometry via electrodynamic modeling. Both the models based on a driven-damped harmonic oscillator and on energy transfers will be applied so that the total decay r... [Phys. Rev. B 86, 155413] Published Tue Oct 09, 2012
    Keywords: Surface physics, nanoscale physics, low-dimensional systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    SEC14L2 enables pan-genotype HCV replication in cell culture (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-08-13
    Description: Since its discovery in 1989, efforts to grow clinical isolates of the hepatitis C virus (HCV) in cell culture have met with limited success. Only the JFH-1 isolate has the capacity to replicate efficiently in cultured hepatoma cells without cell culture-adaptive mutations. We hypothesized that cultured cells lack one or more factors required for the replication of clinical isolates. To identify the missing factors, we transduced Huh-7.5 human hepatoma cells with a pooled lentivirus-based human complementary DNA (cDNA) library, transfected the cells with HCV subgenomic replicons lacking adaptive mutations, and selected for stable replicon colonies. This led to the identification of a single cDNA, SEC14L2, that enabled RNA replication of diverse HCV genotypes in several hepatoma cell lines. This effect was dose-dependent, and required the continuous presence of SEC14L2. Full-length HCV genomes also replicated and produced low levels of infectious virus. Remarkably, SEC14L2-expressing Huh-7.5 cells also supported HCV replication following inoculation with patient sera. Mechanistic studies suggest that SEC14L2 promotes HCV infection by enhancing vitamin E-mediated protection against lipid peroxidation. This provides a foundation for development of in vitro replication systems for all HCV isolates, creating a useful platform to dissect the mechanisms by which cell culture-adaptive mutations act.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632207/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632207/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saeed, Mohsan -- Andreo, Ursula -- Chung, Hyo-Young -- Espiritu, Christine -- Branch, Andrea D -- Silva, Jose M -- Rice, Charles M -- DA031095/DA/NIDA NIH HHS/ -- R01 AI072613/AI/NIAID NIH HHS/ -- R01 AI099284/AI/NIAID NIH HHS/ -- R01 CA057973/CA/NCI NIH HHS/ -- R01 DA031095/DA/NIDA NIH HHS/ -- R01 DK090317/DK/NIDDK NIH HHS/ -- R01AI072613/AI/NIAID NIH HHS/ -- R01AI099284/AI/NIAID NIH HHS/ -- R01CA057973/CA/NCI NIH HHS/ -- R01DK090317/DK/NIDDK NIH HHS/ -- England -- Nature. 2015 Aug 27;524(7566):471-5. doi: 10.1038/nature14899. Epub 2015 Aug 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York 10065, USA. ; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA. ; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26266980" target="_blank"〉PubMed〈/a〉
    Keywords: Antioxidants/metabolism ; Carcinoma, Hepatocellular/genetics/*metabolism/*virology ; Carrier Proteins/genetics/*metabolism ; *Cell Culture Techniques ; Cell Line, Tumor ; Cells, Cultured ; Gene Library ; Genome, Viral/genetics ; *Genotype ; Hepacivirus/*genetics/*growth & development/physiology ; Host-Derived Cellular Factors/genetics/*metabolism ; Humans ; Lentivirus/genetics ; Lipid Peroxidation ; Lipoproteins/genetics/*metabolism ; Mutation/genetics ; RNA, Viral/biosynthesis/genetics ; Replicon/genetics ; Serum/virology ; Trans-Activators/genetics/*metabolism ; Transduction, Genetic ; *Virus Replication/genetics ; Vitamin E/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Synthesis of ultra-incompressible superhard rhenium diboride at ambient pressure (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-04-21
    Description: The quest to create superhard materials rarely strays from the use of high-pressure synthetic methods, which typically require gigapascals of applied pressure. We report that rhenium diboride (ReB2), synthesized in bulk quantities via arc-melting under ambient pressure, rivals materials produced with high-pressure methods. Microindentation measurements on ReB2 indicated an average hardness of 48 gigapascals under an applied load of 0.49 newton, and scratch marks left on a diamond surface confirmed its superhard nature. Its incompressibility along the c axis was equal in magnitude to the linear incompressibility of diamond. In situ high-pressure x-ray diffraction measurements yielded a bulk modulus of 360 gigapascals, and radial diffraction indicated that ReB2 is able to support a remarkably high differential stress. This combination of properties suggests that this material may find applications in cutting when the formation of carbides prevents the use of traditional materials such as diamond.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chung, Hsiu-Ying -- Weinberger, Michelle B -- Levine, Jonathan B -- Cumberland, Robert W -- Kavner, Abby -- Yang, Jenn-Ming -- Tolbert, Sarah H -- Kaner, Richard B -- New York, N.Y. -- Science. 2007 Apr 20;316(5823):436-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry and the California NanoSystems Institute, University of California, Los Angeles, CA 90095-1569, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17446399" target="_blank"〉PubMed〈/a〉
    Keywords: Anisotropy ; Boron Compounds/*chemical synthesis/*chemistry ; Compressive Strength ; Hardness ; Pressure ; Rhenium/*chemistry ; Stress, Mechanical ; X-Ray Diffraction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Phosphadioxirane: a peroxide from an ortho-substituted arylphosphine and singlet dioxygen (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-10-11
    Description: We prepared the primary adduct for the reaction of singlet dioxygen (1O2) with an arylphosphine by using the sterically hindered arylphosphine tris(o-methoxyphenyl)phosphine. The resulting phosphadioxirane has a dioxygen molecule triangularly bound to the phosphorus atom. Olefin trapping experiments show that the phosphadioxirane can undergo nonradical oxygen atom-transfer reactions. Under protic conditions, two different intermediates are formed during the reaction of singlet dioxygen with tris(o-methoxyphenyl)phosphine, namely, the corresponding hydroperoxy arylphosphine and a hydroxy phosphorane. Experiments with other arylphosphines possessing different electronic and steric properties demonstrate that the relative stability of the tris(o-methoxyphenyl)phosphadioxirane is due to both steric and electronic effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ho, David G -- Gao, Ruomei -- Celaje, Jeff -- Chung, Ha-Yong -- Selke, Matthias -- GM 08101/GM/NIGMS NIH HHS/ -- GM 64104/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2003 Oct 10;302(5643):259-62.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, CA 90032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14551430" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry, Physical ; Epoxy Compounds/*chemistry ; Heterocyclic Compounds, 1-Ring/*chemistry ; Kinetics ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Organophosphorus Compounds/*chemistry ; Oxidation-Reduction ; Oxygen/chemistry ; Peroxides/*chemistry ; Phosphines/chemistry ; Phosphorus ; Physicochemical Phenomena ; Singlet Oxygen/chemistry ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Genome-wide copy number variation study in anorectal malformations (2013)
    Oxford University Press
    Details
    Publication Date: 2013-01-12
    Description: Anorectal malformations (ARMs, congenital obstruction of the anal opening) are among the most common birth defects requiring surgical treatment (2–5/10 000 live-births) and carry significant chronic morbidity. ARMs present either as isolated or as part of the phenotypic spectrum of some chromosomal abnormalities or monogenic syndromes. The etiology is unknown. To assess the genetic contribution to ARMs, we investigated single-nucleotide polymorphisms and copy number variations (CNVs) at genome-wide scale. A total of 363 Han Chinese sporadic ARM patients and 4006 Han Chinese controls were included. Overall, we detected a 1.3-fold significant excess of rare CNVs in patients. Stratification of patients by presence/absence of other congenital anomalies showed that while syndromic ARM patients carried significantly longer rare duplications than controls ( P = 0.049), non-syndromic patients were enriched with both rare deletions and duplications when compared with controls ( P = 0.00031). Twelve chromosomal aberrations and 114 rare CNVs were observed in patients but not in 868 controls nor 11 943 healthy individuals from the Database of Genomic Variants. Importantly, these aberrations were observed in isolated ARM patients. Gene-based analysis revealed 79 genes interfered by CNVs in patients only. In particular, we identified a de novo DKK4 duplication . DKK4 is a member of the WNT signaling pathway which is involved in the development of the anorectal region. In mice, Wnt disruption results in ARMs. Our data suggest a role for rare CNVs not only in syndromic but also in isolated ARM patients and provide a list of plausible candidate genes for the disorder.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 7
    Electronic Resource
    Electronic Resource
    Aroma Extract Dilution Analysis of Blue Crab Claw Meat Volatiles (1994)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 42 (1994), S. 2867-2870 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf00048a040
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Observation of resonant and stimulated Raman scattering in ZnSe/CdSe quantum wells grown by atomic layer epitaxy (1993)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 63 (1993), S. 1378-1380 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: This letter reports the successful growth of short period (ZnSe)4/CdSe4 strained layer superlattices on (100) GaAs surface by atomic layer epitaxy. The superlattice was characterized by x-ray diffraction and Raman scattering. Superlattice period was calculated from the satellite peaks and was in good agreement with the expected value. 2LO Raman scattering in resonance with the E1h exciton level was observed. Experimental exciton energy was compared with the one calculated in a finite-square-well model. A Raman line due to stimulated Raman scattering was also observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.109682
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  • 9
    Electronic Resource
    Electronic Resource
    Frequency and distance of transposition of a modifiedDissociation element in transgenic tobacco (1996)
    Springer
    Transgenic research 5 (1996), S. 343-357 
    Details
    ISSN: 1573-9368
    Keywords: heterologous transposon tagging ; Ac/Ds system ; visual transposition assays ; position effects ; Nicotiana tabacum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Effective transposon tagging with theAc/Ds system in heterologous plant species relies on the accomplishment of a potentially high transposon-induced mutation frequency. The primary parameters that determine the mutation frequency include the transposition frequency and the transposition distance. In addition, the development of a generally applicable transposon tagging strategy requires predictable transposition behaviour. We systematically analysedDs transposition frequencies andDs transposition distances in tobacco. An artificialDs element was engineered with reporter genes that allowed transposon excision and integration to be monitored visually. To analyse the variability ofDs transposition between different tobacco lines, eight single copy T-DNA transformants were selected. Fortrans-activation of theDs elements, differentAc lines were used carrying an unmodifiedAc + element, an immobilizedsAc element and a stableAc element under the control of a heterologous chalcone synthas (chsA) promoter. With allAc elements, eachDs line showed characteristic and heritable variegation patterns at the seedling level. SimilarDs line-specificity was observed for the frequency by whichDs transpositions were germinally transmitted, as well as for the distances of theDs transpositions. ThesAc element induced transposition ofDs late in plant development, resulting in low germinal transposition frequencies (0.37%) and high incidences of independent transposition (83%). The majority of theseDs elements (58%) transposed to genetically closed linked sites (≤10 cM).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01968944
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  • 10
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    Notch1 confers a resistance to glucocorticoid-induced apoptosis on developing thymocytes by down-regulating SRG3 expression (2001)
    National Academy of Sciences
    Details
    Publication Date: 2001-08-14
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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