ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Collection
Keywords
Publisher
Years
  • 1
    facet.materialart.
    Unknown
    A forward genetic screen for GBM cancer genes [Medical Sciences] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-10-31
    Description: Neural stem cells (NSCs) are considered to be the cell of origin of glioblastoma multiforme (GBM). However, the genetic alterations that transform NSCs into glioma-initiating cells remain elusive. Using a unique transposon mutagenesis strategy that mutagenizes NSCs in culture, followed by additional rounds of mutagenesis to generate tumors in vivo,...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Characterization of WWP1 protein expression in skeletal muscle of muscular dystrophy chickens (2016)
    Oxford University Press
    Details
    Publication Date: 2016-01-26
    Description: A missense mutation in the gene encoding WWP1 was identified as the most promising candidate responsible for chicken muscular dystrophy (MD) by genetic linkage analysis. WWP1 is a HECT-type E3 ubiquitin protein ligase composed of 922 amino acids, which contains 4 tandem WW domains that interact with the proline-rich peptide motifs of target proteins. The missense mutation changes arginine 441 that is located in the centre of the WW domains into glutamine (R441Q), which potentially affects the function of the WWP1 protein. Here, we show that WWP1 is detected as ~130-kDa protein that localizes to various structures, such as the plasma membrane (sarcolemma), sarcoplasmic reticulum, mitochondria and nucleus, in normal chicken skeletal muscle. However, in MD chickens, the mutant WWP1 protein was markedly degraded and was absent in the sarcolemma. These changes were also observed in the muscles of chickens in early pre-pathological states. Moreover, in vitro expression analysis showed significant degradation of mutant, but not wild-type WWP1, specifically in myogenic cells. Altogether, our data revealed that the R441Q missense mutation in the WWP1 protein causes degradation and loss of the sarcolemmal localization of WWP1, which may play a role in the pathogenesis of chicken MD.
    Print ISSN: 0021-924X
    Electronic ISSN: 1756-2651
    Topics: Biology , Chemistry and Pharmacology
    Published by Oxford University Press on behalf of The Japanese Biochemical Society (JBS).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Functions of innate immune cells and commensal bacteria in gut homeostasis (2016)
    Oxford University Press
    Details
    Publication Date: 2016-01-26
    Description: The intestinal immune system remains unresponsive to beneficial microbes and dietary antigens while activating pro-inflammatory responses against pathogens for host defence. In intestinal mucosa, abnormal activation of innate immunity, which directs adaptive immune responses, causes the onset and/or progression of inflammatory bowel diseases. Thus, innate immunity is finely regulated in the gut. Multiple innate immune cell subsets have been identified in both murine and human intestinal lamina propria. Some innate immune cells play a key role in the maintenance of gut homeostasis by preventing inappropriate adaptive immune responses while others are associated with the pathogenesis of intestinal inflammation through development of Th1 and Th17 cells. In addition, intestinal microbiota and their metabolites contribute to the regulation of innate/adaptive immune responses. Accordingly, perturbation of microbiota composition can trigger intestinal inflammation by driving inappropriate immune responses.
    Print ISSN: 0021-924X
    Electronic ISSN: 1756-2651
    Topics: Biology , Chemistry and Pharmacology
    Published by Oxford University Press on behalf of The Japanese Biochemical Society (JBS).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Candidate for the 2^{+} excited Hoyle state at E_{x}∼10 MeV in ^{12}C (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-11-15
    Description: Author(s): M. Itoh, H. Akimune, M. Fujiwara, U. Garg, N. Hashimoto, T. Kawabata, K. Kawase, S. Kishi, T. Murakami, K. Nakanishi, Y. Nakatsugawa, B. K. Nayak, S. Okumura, H. Sakaguchi, H. Takeda, S. Terashima, M. Uchida, Y. Yasuda, M. Yosoi, and J. Zenihiro [Phys. Rev. C 84, 054308] Published Mon Nov 14, 2011
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer [Medical Sciences] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-01-12
    Description: Mitogen-activated protein kinase (MAPK) pathways regulate multiple cellular functions and are highly active in many types of human cancers. Apoptosis signal-regulating kinase 1 (ASK1) is an upstream MAPK involved in apoptosis, inflammation, and carcinogenesis. This study investigated the role of ASK1 in the development of gastric cancer. In human gastric cancer specimens, we observed increased ASK1 expression, compared to nontumor epithelium. Using a chemically induced murine gastric tumorigenesis model, we observed increased tumor ASK1 expression, and ASK1 knockout mice had both fewer and smaller tumors than wild-type (WT) mice. ASK1 siRNA inhibited cell proliferation through the accumulation of cells in G1 phase of the cell cycle, and reduced cyclin D1 expression in gastric cancer cells, whereas these effects were uncommon in other cancer cells. ASK1 overexpression induced the transcription of cyclin D1, through AP-1 activation, and ASK1 levels were regulated by cyclin D1, via the Rb–E2F pathway. Exogenous ASK1 induced cyclin D1 expression, followed by elevated expression of endogenous ASK1. These results indicate an autoregulatory mechanism of ASK1 in the development of gastric cancer. Targeting this positive feedback loop, ASK1 may present a potential therapeutic target for the treatment of advanced gastric cancer.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Intestinal myeloid cells prevent colitis [Immunology] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-03-28
    Description: Adequate activation of CD4+ T lymphocytes is essential for host defense against invading pathogens; however, exaggerated activity of effector CD4+ T cells induces tissue damage, leading to inflammatory disorders such as inflammatory bowel diseases. Several unique subsets of intestinal innate immune cells have been identified. However, the direct involvement of innate immune cell subsets in the suppression of T-cell-dependent intestinal inflammation is poorly understood. Here, we report that intestinal CX3C chemokine receptor 1high (CX3CR1high) CD11b+ CD11c+ cells are responsible for prevention of intestinal inflammation through inhibition of T-cell responses. These cells inhibit CD4+ T-cell proliferation in a cell contact-dependent manner and prevent T-cell-dependent colitis. The suppressive activity is abrogated in the absence of the IL-10/Stat3 pathway. These cells inhibit T-cell proliferation by two steps. Initially, CX3CR1high CD11b+ CD11c+ cells preferentially interact with T cells through highly expressed intercellular adhesion molecule-1/vascular cell adhesion molecule-1; then, they fail to activate T cells because of defective expression of CD80/CD86. The IL-10/Stat3 pathway mediates the reduction of CD80/CD86 expression. Transfer of wild-type CX3CR1high CD11b+ CD11c+ cells prevents development of colitis in myeloid-specific Stat3-deficient mice. Thus, these cells are regulatory myeloid cells that are responsible for maintaining intestinal homeostasis.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    The widespread occurrence of high-calcium pyroxene in bright-ray craters on the Moon and implications for lunar-crust composition (2011)
    Wiley
    Details
    Publication Date: 2011-09-08
    Description: We investigated the continuous spectral features of fresh craters on the Moon accompanied by distinctive bright rays, with cavity diameters between 8 and 24 km. We used the data from the Spectral Profiler onboard SELENE (Kaguya) to gain a better understanding of the composition of the lunar highland crust. We found that the observed spectra exhibited strong symmetric absorption around 1 μm and recognizable absorption around 1.3 μm. The spectra around a few craters showed a drastic change in the relative strengths of these two absorption bands s1.3/1.0 at different locations in and around the craters, indicating differences in the abundance of plagioclase and mafic minerals. In contrast, the spectra around most of the craters showed no significant variation in spectral shape, with an essentially constant s1.3/1.0. We analyzed the absorption features of the craters with an essentially constant s1.3/1.0 using the Modified Gaussian Model. We found that the strongest symmetric absorption bands were centered at 0.97–1.01 μm with s1.3/1.0 ≈ 0.2–0.6. Comparing these values with data from known samples, we concluded that high-calcium pyroxene (HCP) is the most plausible dominant mafic mineral identified from the observed spectra. The fact that we detected such HCP-dominant spectra among rayed craters widely spaced across the lunar highland implies that the major mafic component of some portions of the lunar crust is HCP rather than low-calcium pyroxene (LCP).
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Growth, structure and electrical properties of aluminum substituted langasite family crystals (2011)
    Institute of Physics (IOP)
    Details
    Publication Date: 2011-09-15
    Description: We report aluminium substitution effect on structure and electric properties of langasite (La 3 Ga 5 SiO 14 ) family crystals. Quasi-congruent melting composition of La 3 Ga 5-x Al x SiO 14 (LGAS), La 3 Nb 0.5 Ga 5.5-x Al x O 14 (LNGA), and La 3 Ta 0.5 Ga 5.5-x Al x O 14 (LTGA) crystals are x = 0.9, 0.2, and 0.5, respectively. A single-crystal x-ray structure analysis reveals that Al atoms are distributed in all cation sites except for the decahedral one occupied by La, by rather favoring the smallest tetrahedral one. The electrical properties of the Al-substituted crystals are compared with those of pure ones. By Al substitution, all langasite family crystals show higher piezoelectric constant d 11 and higher electric resistivity ρ . Among them, the LTGA crystal with lower temperature dependence...
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-12-05
    Description: Cilia and flagella are highly conserved organelles that have diverse roles in cell motility and sensing extracellular signals. Motility defects in cilia and flagella often result in primary ciliary dyskinesia. However, the mechanisms underlying cilia formation and function, and in particular the cytoplasmic assembly of dyneins that power ciliary motility, are only poorly understood. Here we report a new gene, kintoun (ktu), involved in this cytoplasmic process. This gene was first identified in a medaka mutant, and found to be mutated in primary ciliary dyskinesia patients from two affected families as well as in the pf13 mutant of Chlamydomonas. In the absence of Ktu/PF13, both outer and inner dynein arms are missing or defective in the axoneme, leading to a loss of motility. Biochemical and immunohistochemical studies show that Ktu/PF13 is one of the long-sought proteins involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279746/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279746/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Omran, Heymut -- Kobayashi, Daisuke -- Olbrich, Heike -- Tsukahara, Tatsuya -- Loges, Niki T -- Hagiwara, Haruo -- Zhang, Qi -- Leblond, Gerard -- O'Toole, Eileen -- Hara, Chikako -- Mizuno, Hideaki -- Kawano, Hiroyuki -- Fliegauf, Manfred -- Yagi, Toshiki -- Koshida, Sumito -- Miyawaki, Atsushi -- Zentgraf, Hanswalter -- Seithe, Horst -- Reinhardt, Richard -- Watanabe, Yoshinori -- Kamiya, Ritsu -- Mitchell, David R -- Takeda, Hiroyuki -- GM44228/GM/NIGMS NIH HHS/ -- R01 GM044228/GM/NIGMS NIH HHS/ -- R01 GM044228-17/GM/NIGMS NIH HHS/ -- England -- Nature. 2008 Dec 4;456(7222):611-6. doi: 10.1038/nature07471.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg Mathildenstrasse 1, D-79106 Freiburg, Germany. heymut.omran@uniklinik-freiburg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19052621" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axoneme/chemistry/genetics/*metabolism/pathology ; Chlamydomonas/genetics/metabolism ; Cilia/chemistry/genetics/*metabolism/pathology ; Cloning, Molecular ; Dyneins/*metabolism ; Epithelial Cells/cytology ; Fish Proteins/genetics/*metabolism ; Genes, Recessive/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Humans ; Kartagener Syndrome/genetics/pathology ; Male ; Mice ; Molecular Sequence Data ; Mutation/genetics ; *Oryzias/embryology/genetics/metabolism ; Protein Binding ; Proteins/genetics/*metabolism ; Sequence Homology, Amino Acid ; Sperm Motility ; Testis/cytology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    The global distribution of pure anorthosite on the Moon (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-09-11
    Description: It has been thought that the lunar highland crust was formed by the crystallization and floatation of plagioclase from a global magma ocean, although the actual generation mechanisms are still debated. The composition of the lunar highland crust is therefore important for understanding the formation of such a magma ocean and the subsequent evolution of the Moon. The Multiband Imager on the Selenological and Engineering Explorer (SELENE) has a high spatial resolution of optimized spectral coverage, which should allow a clear view of the composition of the lunar crust. Here we report the global distribution of rocks of high plagioclase abundance (approaching 100 vol.%), using an unambiguous plagioclase absorption band recorded by the SELENE Multiband Imager. If the upper crust indeed consists of nearly 100 vol.% plagioclase, this is significantly higher than previous estimates of 82-92 vol.% (refs 2, 6, 7), providing a valuable constraint on models of lunar magma ocean evolution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ohtake, Makiko -- Matsunaga, Tsuneo -- Haruyama, Junichi -- Yokota, Yasuhiro -- Morota, Tomokatsu -- Honda, Chikatoshi -- Ogawa, Yoshiko -- Torii, Masaya -- Miyamoto, Hideaki -- Arai, Tomoko -- Hirata, Naru -- Iwasaki, Akira -- Nakamura, Ryosuke -- Hiroi, Takahiro -- Sugihara, Takamitsu -- Takeda, Hiroshi -- Otake, Hisashi -- Pieters, Carle M -- Saiki, Kazuto -- Kitazato, Kohei -- Abe, Masanao -- Asada, Noriaki -- Demura, Hirohide -- Yamaguchi, Yasushi -- Sasaki, Sho -- Kodama, Shinsuke -- Terazono, Junya -- Shirao, Motomaro -- Yamaji, Atsushi -- Minami, Shigeyuki -- Akiyama, Hiroaki -- Josset, Jean-Luc -- England -- Nature. 2009 Sep 10;461(7261):236-40. doi: 10.1038/nature08317.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, 3-1-1 Yoshino-dai, Sagamihara, Kanagawa 229-8510, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19741704" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...