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  • 1
    Monograph non-lending collection
    Monograph non-lending collection
    Absolute Messung der Schwerkraft in Kyõto, Kanazawa, Tõky¶o und Mizusawa mit Reversionspendeln ausgeführt
    Tokyo
    Details Availability
    Call number: Q 371 / Regal 52,2
    Type of Medium: Monograph non-lending collection
    Pages: 91 S.
    Series Statement: Journal of the College of Science, Imperial University, Tokyo, Japan vol. xvi, Article 11
    Location: Magazine - must be ordered
    Branch Library: GFZ Library
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  • 2
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    Degradation of hyaluronan by KIAA1199 [Medical Sciences] (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-04-03
    Description: Hyaluronan (HA) has an extraordinarily high turnover in physiological tissues, and HA degradation is accelerated in inflammatory and neoplastic diseases. CD44 (a cell surface receptor) and two hyaluronidases (HYAL1 and HYAL2) are thought to be responsible for HA binding and degradation; however, the role of these molecules in HA catabolism...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-11-16
    Description: Activation-induced cytidine deaminase (AID) plays an essential role in class switch recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin genes. We report here that deficiency in AID results in the development of hyperplasia of isolated lymphoid follicles (ILFs) associated with a 100-fold expansion of anaerobic flora in the small intestine. Reduction of bacterial flora by antibiotic treatment of AID-/- mice abolished ILF hyperplasia as well as the germinal center enlargement seen in secondary lymphoid tissues. Because an inability to switch to immunoglobulin A on its own does not lead to a similar phenotype, these results suggest that SHM of ILF B cells plays a critical role in regulating intestinal microflora.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fagarasan, Sidonia -- Muramatsu, Masamichi -- Suzuki, Keiichiro -- Nagaoka, Hitoshi -- Hiai, Hiroshi -- Honjo, Tasuku -- New York, N.Y. -- Science. 2002 Nov 15;298(5597):1424-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12434060" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents ; B-Lymphocytes/immunology ; Bacteria, Aerobic/*growth & development ; Bacteria, Anaerobic/*growth & development ; Cell Division ; Colony Count, Microbial ; Cytidine Deaminase/genetics/*metabolism ; Dendritic Cells, Follicular/immunology ; Drug Therapy, Combination/pharmacology ; Genes, Immunoglobulin ; Germinal Center/immunology ; Homeostasis ; Hyperplasia ; Immunization ; Immunoglobulin Class Switching ; Immunoglobulin Variable Region/genetics ; Intestine, Small/immunology/*microbiology ; Lymphocyte Activation ; Lymphoid Tissue/immunology/*pathology ; Metronidazole/pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Peyer's Patches/pathology ; Somatic Hypermutation, Immunoglobulin ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-06-18
    Description: Activation-induced cytidine deaminase (AID), a putative RNA-editing enzyme, is indispensable for somatic hypermutation (SHM), class switch recombination, and gene conversion of immunoglobulin genes, which indicates a common molecular mechanism for these phenomena. Here we show that ectopic expression of AID alone can induce hypermutation in an artificial GFP substrate in NIH 3T3 murine fibroblast cells. The frequency of mutations was closely correlated with the level of transcription of the target gene, and the distribution of mutations in NIH 3T3 cells was similar to those of SHM in B lymphocytes. These results indicate that AID is sufficient for the generation of SHM in an actively transcribed gene in fibroblasts, as well as B cells, and that any of the required cofactors must be present in these fibroblasts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoshikawa, Kiyotsugu -- Okazaki, Il-Mi -- Eto, Tomonori -- Kinoshita, Kazuo -- Muramatsu, Masamichi -- Nagaoka, Hitoshi -- Honjo, Tasuku -- New York, N.Y. -- Science. 2002 Jun 14;296(5575):2033-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medical Chemistry and Molecular Biology, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12065838" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Animals ; B-Lymphocytes/physiology ; Base Sequence ; Cytidine Deaminase/genetics/*metabolism ; DNA/chemistry/genetics ; Genes, Reporter ; Green Fluorescent Proteins ; Luminescent Proteins/genetics/metabolism ; Mice ; Molecular Sequence Data ; *Mutation ; Nucleic Acid Conformation ; Point Mutation ; Recombinant Proteins/metabolism ; Somatic Hypermutation, Immunoglobulin ; Transcription, Genetic ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-08-25
    Description: Activation-induced cytidine deaminase (AID) is required for the DNA cleavage step in immunoglobulin class switch recombination (CSR). AID is proposed to deaminate cytosine to generate uracil (U) in either mRNA or DNA. In the second instance, DNA cleavage depends on uracil DNA glycosylase (UNG) for removal of U. Using phosphorylated histone gamma-H2AX focus formation as a marker of DNA cleavage, we found that the UNG inhibitor Ugi did not inhibit DNA cleavage in immunoglobulin heavy chain (IgH) locus during CSR, even though Ugi blocked UNG binding to DNA and strongly inhibited CSR. Strikingly, UNG mutants that had lost the capability of removing U rescued CSR in UNG-/- B cells. These results indicate that UNG is involved in the repair step of CSR yet by an unknown mechanism. The dispensability of U removal in the DNA cleavage step of CSR requires a reconsideration of the model of DNA deamination by AID.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Begum, Nasim A -- Kinoshita, Kazuo -- Kakazu, Naoki -- Muramatsu, Masamichi -- Nagaoka, Hitoshi -- Shinkura, Reiko -- Biniszkiewicz, Detlev -- Boyer, Laurie A -- Jaenisch, Rudolf -- Honjo, Tasuku -- New York, N.Y. -- Science. 2004 Aug 20;305(5687):1160-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medical Chemistry and Molecular Biology, Graduate School of Medicine, Kyoto University, Yoshida Sakyo-ku, Kyoto 606-8501, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15326357" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/enzymology/immunology/*physiology ; Cell Line, Tumor ; Cytidine Deaminase/metabolism ; DNA/*metabolism ; DNA Glycosylases/antagonists & inhibitors/genetics/*metabolism ; DNA Repair ; *Genes, Immunoglobulin ; *Immunoglobulin Class Switching ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Switch Region ; Mice ; Mutation ; Precipitin Tests ; Recombination, Genetic ; Transfection ; Uracil/metabolism ; Uracil-DNA Glycosidase ; Viral Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Solar cells. Impact of microstructure on local carrier lifetime in perovskite solar cells (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-05-02
    Description: The remarkable performance of hybrid perovskite photovoltaics is attributed to their long carrier lifetimes and high photoluminescence (PL) efficiencies. High-quality films are associated with slower PL decays, and it has been claimed that grain boundaries have a negligible impact on performance. We used confocal fluorescence microscopy correlated with scanning electron microscopy to spatially resolve the PL decay dynamics from films of nonstoichiometric organic-inorganic perovskites, CH3NH3PbI3(Cl). The PL intensities and lifetimes varied between different grains in the same film, even for films that exhibited long bulk lifetimes. The grain boundaries were dimmer and exhibited faster nonradiative decay. Energy-dispersive x-ray spectroscopy showed a positive correlation between chlorine concentration and regions of brighter PL, whereas PL imaging revealed that chemical treatment with pyridine could activate previously dark grains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉deQuilettes, Dane W -- Vorpahl, Sarah M -- Stranks, Samuel D -- Nagaoka, Hirokazu -- Eperon, Giles E -- Ziffer, Mark E -- Snaith, Henry J -- Ginger, David S -- EB-002027/EB/NIBIB NIH HHS/ -- New York, N.Y. -- Science. 2015 May 8;348(6235):683-6. doi: 10.1126/science.aaa5333. Epub 2015 Apr 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195-1700, USA. ; Clarendon Laboratory, University of Oxford, Parks Road, Oxford OX1 3PU, UK. ; Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195-1700, USA. ginger@chem.washington.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25931446" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Mitotic catastrophe and cell death induced by depletion of centrosomal proteins (2013)
    Springer Nature
    Details
    Publication Date: 2013-04-19
    Description: Mitotic catastrophe and cell death induced by depletion of centrosomal proteins Cell Death and Disease 4, e603 (April 2013). doi:10.1038/cddis.2013.108 Authors: M Kimura, T Yoshioka, M Saio, Y Banno, H Nagaoka & Y Okano
    Keywords: centrosomecheckpointapoptosismitotic catastrophep53caspase
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 8
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    Potassium and thorium abundances at the South Pole‐Aitken basin obtained by the Kaguya Gamma‐ray Spectrometer (2019)
    Wiley
    Details
    Publication Date: 2019
    Description: Abstract In this study, we present detailed K and Th distribution maps of the South Pole‐Aitken (SPA) basin with a (100 km)2 resolution for the compositional and evolutional studies. These maps have been constructed for the first time from the Kaguya Gamma‐Ray Spectrometer (KGRS) datasets acquired during SELENE (Kaguya) low‐altitude observations at 50km. The K and Th distribution maps are compared with those obtained by KGRS high‐altitude observation, and LP GRS high‐ and low‐altitude observations. The use of KGRS low‐altitude datasets with high energy resolution enable to obtain unambiguous counts of individual gamma‐ray lines, leading precise elemental maps of K and Th comparing to previous studies. K and Th abundances at the areas of some large impact craters infilled with mare deposits are lower than that in surrounding regions. Geologic maps of the SPA region obtained by the Kaguya Multiband Imager are assimilated and confirmed based on the K and Th distributions. The evolution hypothesis of the SPA region based on the SPA giant impact event suggested by some previous model studies is also confirmed.
    Print ISSN: 2169-9097
    Electronic ISSN: 2169-9100
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 9
    Electronic Resource
    Electronic Resource
    Total synthesis of rifamycins. 2. Total synthesis of racemic rifamycin S (1980)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 102 (1980), S. 7965-7967 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00547a038
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  • 10
    Electronic Resource
    Electronic Resource
    Total synthesis of rifamycins. 1. Stereocontrolled synthesis of the aliphatic building block (1980)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 102 (1980), S. 7962-7965 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00547a037
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