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  • 1
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    Biopolymer network micromechanics [Physics] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-09-16
    Description: Collagen gels are widely used in experiments on cell mechanics because they mimic the extracellular matrix in physiological conditions. Collagen gels are often characterized by their bulk rheology; however, variations in the collagen fiber microstructure and cell adhesion forces cause the mechanical properties to be inhomogeneous at the cellular scale....
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Radiation of sound from circular pipe (1948)
    In:  Phys. Rev., Luxembourg, Conseil de l'Europe, vol. 73, no. 11, pp. 383, pp. B02405, (ISSN: 1340-4202)
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    Publication Date: 1948
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    BIBLIOGRAPHY SEISMOLOGY
  • 3
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    Embodied Resource Flows in a Global Economy (2012)
    Wiley
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    Publication Date: 2012-07-18
    Description: This article presents a methodology for identifying critical links in global resource supply chains by tracking resources from their extraction in one region of the world economy through their embodiment in intermediate products in the same and other regions to eventual embodiment in final goods. We build on previous work that applied an absorbing Markov chain (AMC) to results obtained using an input-output (IO) model of a single region to define a resource-specific network within that economy. In the absence of model calculations, the AMC can also be applied to standard IO data for a past year. This article first generalizes the analytic framework from a single region to the important case of the global resource-specific network. This network typically includes cycling of embodied resources between sectors not only within each economy, but also among regions, as subsequent rounds of intermediate products are traded. Next, we refine that analysis to exhibit a crucial subnetwork, the resource end-use network, which only tracks the portion of the resource that ends up embodied in a specific final product in a given region. Finally, we develop techniques to distinguish key branches of these networks and provide detailed insights about the structure of global resource dependence. A numerical example is applied to results of scenario analysis using an IO model of the world economy. Two alternative scenarios are compared. In each scenario, embodied resources are carried over specific branches of a global network in three regions using three resources to produce four goods.
    Print ISSN: 1088-1980
    Electronic ISSN: 1530-9290
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Wiley
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  • 4
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    On the strong and selective isotope effect in the UV excitation of N2 with implications toward the nebula and Martian atmosphere [Physics] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-04-13
    Description: Isotopic effects associated with molecular absorption are discussed with reference to natural phenomena including early solar system processes, Titan and terrestrial atmospheric chemistry, and Martian atmospheric evolution. Quantification of the physicochemical aspects of the excitation and dissociation processes may lead to enhanced understanding of these environments. Here we examine a physical basis for an additional isotope effect during photolysis of molecular nitrogen due to the coupling of valence and Rydberg excited states. The origin of this isotope effect is shown to be the coupling of diabatic electronic states of different bonding nature that occurs after the excitation of these states. This coupling is characteristic of energy regimes where two or more excited states are nearly crossing or osculating. A signature of the resultant isotope effect is a window of rapid variation in the otherwise smooth distribution of oscillator strengths vs. frequency. The reference for the discussion is the numerical solution of the time dependent Schrödinger equation for both the electronic and nuclear modes with the light field included as part of the Hamiltonian. Pumping is to all extreme UV dipole-allowed, valence and Rydberg, excited states of N2. The computed absorption spectra are convoluted with the solar spectrum to demonstrate the importance of including this isotope effect in planetary, interstellar molecular cloud, and nebular photochemical models. It is suggested that accidental resonance with strong discrete lines in the solar spectrum such as the CIII line at 97.703 nm can also have a marked effect.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 5
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    Self-assembly of Janus dendrimers into uniform dendrimersomes and other complex architectures (2010)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2010-05-22
    Description: Self-assembled nanostructures obtained from natural and synthetic amphiphiles serve as mimics of biological membranes and enable the delivery of drugs, proteins, genes, and imaging agents. Yet the precise molecular arrangements demanded by these functions are difficult to achieve. Libraries of amphiphilic Janus dendrimers, prepared by facile coupling of tailored hydrophilic and hydrophobic branched segments, have been screened by cryogenic transmission electron microscopy, revealing a rich palette of morphologies in water, including vesicles, denoted dendrimersomes, cubosomes, disks, tubular vesicles, and helical ribbons. Dendrimersomes marry the stability and mechanical strength obtainable from polymersomes with the biological function of stabilized phospholipid liposomes, plus superior uniformity of size, ease of formation, and chemical functionalization. This modular synthesis strategy provides access to systematic tuning of molecular structure and of self-assembled architecture.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Percec, Virgil -- Wilson, Daniela A -- Leowanawat, Pawaret -- Wilson, Christopher J -- Hughes, Andrew D -- Kaucher, Mark S -- Hammer, Daniel A -- Levine, Dalia H -- Kim, Anthony J -- Bates, Frank S -- Davis, Kevin P -- Lodge, Timothy P -- Klein, Michael L -- DeVane, Russell H -- Aqad, Emad -- Rosen, Brad M -- Argintaru, Andreea O -- Sienkowska, Monika J -- Rissanen, Kari -- Nummelin, Sami -- Ropponen, Jarmo -- New York, N.Y. -- Science. 2010 May 21;328(5981):1009-14. doi: 10.1126/science.1185547.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323, USA. percec@sas.upenn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20489021" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiotics, Antineoplastic/administration & dosage ; Biomimetic Materials/chemistry ; Cryoelectron Microscopy ; Dendrimers/*chemistry ; Doxorubicin/administration & dosage ; Drug Carriers ; Hydrophobic and Hydrophilic Interactions ; *Membranes, Artificial ; Models, Molecular ; Molecular Dynamics Simulation ; Molecular Structure ; *Nanostructures ; Surface Properties ; Surface-Active Agents/chemistry ; Water
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    The rectangular sector-by-technology model: not every economy produces every product and some products may rely on several technologies simultaneously (2016)
    SpringerOpen
    Details
    Publication Date: 2016-02-11
    Description: This paper identifies a fundamental challenge in the development of input-output databases of the world economy intended for analysis of alternative scenarios with a model of the world economy. Primary data so...
    Electronic ISSN: 2193-2409
    Topics: Economics
    Published by SpringerOpen
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  • 7
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    Ph.d. Education (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-07-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, Z H -- New York, N.Y. -- Science. 1995 Jul 7;269(5220):17.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17787683" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Functional roles of pulsing in genetic circuits (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-07
    Description: A fundamental problem in biology is to understand how genetic circuits implement core cellular functions. Time-lapse microscopy techniques are beginning to provide a direct view of circuit dynamics in individual living cells. Unexpectedly, we are discovering that key transcription and regulatory factors pulse on and off repeatedly, and often stochastically, even when cells are maintained in constant conditions. This type of spontaneous dynamic behavior is pervasive, appearing in diverse cell types from microbes to mammalian cells. Here, we review recent work showing how pulsing is generated and controlled by underlying regulatory circuits and how it provides critical capabilities to cells in stress response, signaling, and development. A major theme is the ability of pulsing to enable time-based regulation analogous to strategies used in engineered systems. Thus, pulsatile dynamics is emerging as a central, and still largely unexplored, layer of temporal organization in the cell.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100686/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100686/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, Joe H -- Lin, Yihan -- Elowitz, Michael B -- P50GM068763/GM/NIGMS NIH HHS/ -- R01 GM079771/GM/NIGMS NIH HHS/ -- R01 GM079771-06/GM/NIGMS NIH HHS/ -- R01 GM086793A/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Dec 6;342(6163):1193-200. doi: 10.1126/science.1239999.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24311681" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bacterial Physiological Phenomena ; Cell Differentiation ; *Cell Physiological Phenomena ; *Gene Expression Regulation ; *Gene Regulatory Networks ; Signal Transduction ; Single-Cell Analysis ; Stress, Physiological
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3 (2017)
    American Chemical Society (ACS)
    Details
    Publication Date: 2017-10-11
    Description: Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.7b00922
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 10
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    Crystalline anisotropy (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, H -- Koplik, J -- New York, N.Y. -- Science. 1984 Aug 10;225(4662):566.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17729827" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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