Publication Date:
2016-02-05
Description:
Article TLX is a nuclear receptor essential for neural stem cell self-renewal and recently involved in glioblastoma development. In this study, the authors show that inhibition of TLX expression, achieved using a dendrimer nanovector-delivered siRNAs or viral vector-delivered shRNAs, reduces glioblastoma stem cells self renewal and in vivo tumour growth through activation of TET3. Nature Communications doi: 10.1038/ncomms10637 Authors: Qi Cui, Su Yang, Peng Ye, E. Tian, Guoqiang Sun, Jiehua Zhou, Guihua Sun, Xiaoxuan Liu, Chao Chen, Kiyohito Murai, Chunnian Zhao, Krist T. Azizian, Lu Yang, Charles Warden, Xiwei Wu, Massimo D'Apuzzo, Christine Brown, Behnam Badie, Ling Peng, Arthur D. Riggs, John J. Rossi, Yanhong Shi
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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