ISSN:
1432-0703
Source:
Springer Online Journal Archives 1860-2000
Topics:
Energy, Environment Protection, Nuclear Power Engineering
,
Medicine
Notes:
Abstract Spiking blood with14C-labeled 2,2′, 4,4′,5,5′-hexabromobiphenyl (14C-HxBB) or a mixture of 2,2′,4,5,5′-pentabromobiphenyl, 2,2′,4,5′,6-pentabromobiphenyl and14C-HxBB has been found, in comparative measurements, to be a representative model of polybrominated biphenyl (PBB) contaminated blood from Michigan residents. Blood components were obtained by Ficoll-Hypaque techniques, apolipoprotein B and A fractions by immunoprecipitation with specific antisera; congeners were quantified by negative chemical ionization mass spectrometry or scintillation counting. The distribution of PBB among plasma, erythrocytes, mononucleocytes and polymorphonucleocytes was 89:9:⩽1:⩽1. In serum, 20% of the PBB was not bound to protein. The remaining 80% was bound to apolipoproteins B and A in a 4∶1 ratio, which is close to the ratio (by weight) of the lipid content of these apolipoproteins. No preferential absorption of PBB congeners occurred in the examined blood compartments.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01055603
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