ISSN:
1040-0397
Keywords:
Adsorptive stripping voltammetry
;
Cinoxacin
;
Urine analysis
;
Human plasma analysis
;
Experimental design
;
Regression modelling
;
Response surface plot
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The quinolone antibacterial agent cinoxacin was studied by adsorptive stripping voltammetry making use of its controlled interfacial accumulation on a static mercury drop electrode. Measurements were obtained in differential pulse mode and optimized by experimental design. The chemometric approach allowed the identification of a strong interaction between pH and pulse amplitude. The dynamic linear range of calibration was extended from 0.4 to 9 × 10-8 M. Analyses of cinoxacin capsules and spiked human urine sample were carried out without the need of previous extraction or filtration. A cleanup procedure was required to separate cinoxacin from the human plasma matrix prior to adsorptive stripping analysis.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/elan.1140071212
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