ISSN:
1573-3904
Keywords:
Pseudopeptides
;
Phosphonamidates
;
Immunomodulators
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Two phosphono desmuramyldipeptide analogs, 6 and 11, were synthesized and evaluated for immunomodulatory activity. Phthalimido-and adamantyl-substituted side chains as a replacement for the N-acetylmuraminic acid were coupled with appropriate dipeptides using DPPA as the coupling reagent. Introduction of a phosphonamidate moiety in compound 6 resulted in lower biological activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00119151
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