ISSN:
1573-739X
Keywords:
Adsorption
;
Drug stability
;
Parenteral nutrition
;
Somatostatin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The stability of somatostatin, added to a total parenteral nutrition formula, in glass containers and in plastic ethylene vinyl acetate containers was investigated. The somatostatin concentration decreased immediately from 3μg/ml to 0.3–0.6μg/ml after addition to the emulsion. In spite of this rapid decrease, somatostatin concentrations remained stable with values of 0.4–0.7μg/ml during the follow-up period (24 h). These findings could be explained assuming adsorption to the surface of the container.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01967824
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