Publication Date:
2000-03-31
Description:
Autoimmunity arises when immune tolerance to specific self-antigens is broken. The mechanisms leading to such a failure remain poorly understood. One hypothesis proposes that infectious agents or antigens can break B or T lymphocyte self-tolerance by expressing epitopes that mimic self. Using a transgenic immunoglobulin model, we show that challenge with self-mimicking foreign antigen rescues B cells from peripheral tolerance independent of T cell help, resulting in the accumulation of self-reactive cells in the lymph nodes and secretion of immunoglobulins that bind to a liver-expressed self-antigen. Therefore, our studies reveal a potentially important mechanism by which B lymphocytes can escape self-tolerance.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786169/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786169/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kouskoff, V -- Lacaud, G -- Nemazee, D -- P01AI22295/AI/NIAID NIH HHS/ -- R01 GM044809/GM/NIGMS NIH HHS/ -- R01AI33608/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2000 Mar 31;287(5462):2501-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10741972" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, T-Independent/*immunology
;
Autoantibodies/analysis
;
Autoantigens/*immunology
;
B-Lymphocytes/*immunology
;
Bone Marrow/immunology
;
Clonal Deletion
;
Cross Reactions
;
H-2 Antigens/immunology
;
Immunization
;
Immunoglobulin M/analysis
;
Liver/immunology
;
Lymph Nodes/immunology
;
Lymphocyte Activation
;
Mice
;
Mice, Transgenic
;
*Molecular Mimicry
;
Receptors, Antigen, B-Cell/immunology
;
*Self Tolerance
;
T-Lymphocytes/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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