Publication Date:
2015-03-15
Description:
Sepsis is a frequently fatal condition characterized by an uncontrolled and harmful host reaction to microbial infection. Despite the prevalence and severity of sepsis, we lack a fundamental grasp of its pathophysiology. Here we report that the cytokine interleukin-3 (IL-3) potentiates inflammation in sepsis. Using a mouse model of abdominal sepsis, we showed that innate response activator B cells produce IL-3, which induces myelopoiesis of Ly-6C(high) monocytes and neutrophils and fuels a cytokine storm. IL-3 deficiency protects mice against sepsis. In humans with sepsis, high plasma IL-3 levels are associated with high mortality even after adjusting for prognostic indicators. This study deepens our understanding of immune activation, identifies IL-3 as an orchestrator of emergency myelopoiesis, and reveals a new therapeutic target for treating sepsis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376966/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376966/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weber, Georg F -- Chousterman, Benjamin G -- He, Shun -- Fenn, Ashley M -- Nairz, Manfred -- Anzai, Atsushi -- Brenner, Thorsten -- Uhle, Florian -- Iwamoto, Yoshiko -- Robbins, Clinton S -- Noiret, Lorette -- Maier, Sarah L -- Zonnchen, Tina -- Rahbari, Nuh N -- Scholch, Sebastian -- Klotzsche-von Ameln, Anne -- Chavakis, Triantafyllos -- Weitz, Jurgen -- Hofer, Stefan -- Weigand, Markus A -- Nahrendorf, Matthias -- Weissleder, Ralph -- Swirski, Filip K -- 5R01HL095612/HL/NHLBI NIH HHS/ -- R01 HL095612/HL/NHLBI NIH HHS/ -- R56 AI104695/AI/NIAID NIH HHS/ -- R56-AI104695/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2015 Mar 13;347(6227):1260-5. doi: 10.1126/science.aaa4268.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Department of Visceral, Thoracic and Vascular Surgery, Technische Universitat Dresden, Dresden, Germany. fswirski@mgh.harvard.edu georg.weber@uniklinikum-dresden.de. ; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. ; Department of Anesthesiology, University of Heidelberg, Heidelberg, Germany. ; Department of Visceral, Thoracic and Vascular Surgery, Technische Universitat Dresden, Dresden, Germany. ; Department of Clinical Pathobiochemistry and Institute for Clinical Chemistry and Laboratory Medicine, Technische Universitat Dresden, Dresden, Germany. ; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. ; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. fswirski@mgh.harvard.edu georg.weber@uniklinikum-dresden.de.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25766237" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
B-Lymphocyte Subsets/immunology
;
Cytokines/immunology/metabolism
;
Disease Models, Animal
;
Humans
;
Inflammation
;
Interleukin-3/blood/*immunology/metabolism
;
Lipopolysaccharides/immunology
;
Lymphoid Tissue/immunology
;
Mice
;
Mice, Inbred BALB C
;
Monocytes/immunology
;
Myelopoiesis
;
Neutrophils/immunology
;
Peritonitis/immunology/pathology
;
Prognosis
;
Sepsis/*immunology/mortality/pathology/therapy
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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