ISSN:
1432-1041
Keywords:
Penta-acetyl-gitoxin
;
16-acetyl-gitoxin
;
gitoxin
;
mass spectrometry
;
species-specific deacylation
;
man
;
rabbit
;
guinea-pig
;
rat
;
blood
;
intestinal mucosa
;
liver homogenate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Penta-acetyl-gitoxin (PAG) shows species-specific deacylation to 16-acetyl-gitoxin (16-AG; I and III) or gitoxin (II and IV) by homogenates of liver and intestinal mucosa of man (I), rabbit (II), guinea-pig (III) and rat (IV), whereas it is degraded into tri- and tetra-acetates by homogenates of guinea-pig myocardium as well as by human blood and serum. The identity of the principal and chloroform-extractable metabolites in human urine after PAG administration with 16-AG has been demonstrated by mass spectrometry.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00716384
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