Publication Date:
2016-07-14
Description:
Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma Nature 535, 7611 (2016). doi:10.1038/nature18632 Authors: John T. Powers, Kaloyan M. Tsanov, Daniel S. Pearson, Frederik Roels, Catherine S. Spina, Richard Ebright, Marc Seligson, Yvanka de Soysa, Patrick Cahan, Jessica Theißen, Ho-Chou Tu, Areum Han, Kyle C. Kurek, Grace S. LaPier, Jihan K. Osborne, Samantha J. Ross, Marcella Cesana, James J. Collins, Frank Berthold & George Q. Daley Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN. MYCN is itself a target of let-7, a tumour suppressor family of microRNAs implicated in numerous cancers. LIN28B, an inhibitor of let-7 biogenesis, is overexpressed in neuroblastoma and has
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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