Electronic Resource
Palo Alto, Calif.
:
Annual Reviews
Annual Review of Biomedical Engineering
2 (2000), S. 227-256
ISSN:
1523-9829
Source:
Annual Reviews Electronic Back Volume Collection 1932-2001ff
Topics:
Technology
,
Medicine
Notes:
Abstract Tissue function is modulated by an intricate architecture of cells and biomolecules on a micrometer scale. Until now, in vitro cellular interactions were mainly studied by random seeding over homogeneous substrates. Although this strategy has led to important discoveries, it is clearly a nonoptimal analog of the in vivo scenario. With the incorporation-and adaptation-of microfabrication technology into biology, it is now possible to design surfaces that reproduce some of the aspects of that architecture. This article reviews past research on the engineering of cell-substrate, cell-cell, and cell-medium interactions on the micrometer scale.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1146/annurev.bioeng.2.1.227
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