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Immunobiology of gonococcal outer membrane protein I (1987)

Heckels, J. E. ; Virji, M. ; Zak, K. ; [et al.]

Springer

Antonie van Leeuwenhoek 53 (1987), S. 461-464

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ISSN: 1572-9699

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract Monoclonal antibodies have been obtained which react with gonococcal outer membrane protein I. One antibody recognised the majority of strains expressing P.IA and another recognised the majority of strains expressing P.IB. In in vitro tests both antibodies were bactericidal in the presence of complement, opsonic for phagocytosis by human PMN and protected epithelial cells against gonococcal invasion. Thus conserved epitopes on P.I. are potentially effective targets for immunoprophylaxis.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00415503

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