Publication Date:
2011-08-31
Description:
Based on the crystal structure of the budding yeast Kluyveromyces lactis (Kl) Scm3–Cse4–H4 complex and the proteolysis results of the budding yeast Saccharomyces cerevisiae (Sc) Scm3–Cse4–H4 complex, Cho and Harrison (1) questioned our NMR structure of the Sc Scm3–Cse4–H4 complex (2), stating that “The construct deleted helix I of H4, however, and this deletion, together with omission of about 20 residues in the N-terminal part of the conserved region of Scm3, appears to have generated severe distortions in about half the structure, leading to incorrect conclusions about histone conformational differences and about a number of the Scm3-Cse4 contacts.”The statement by...
Keywords:
Letters
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
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