ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Simple bifunctional carboxy- and phospho-protecting groups are described which allow the attachment of protected amino acids and nucleotides to soluble or insoluble carriers. After chemical synthesis with conventional procedures, the completed oligopeptides or oligonucleotides can be detached by base-catalyzed β-elimination, leaving other protecting groups intact. These protected biopolymer segments can then be purified, characterized, and used for further synthetic work by virtue of their free carboxy or phospho groups. It is also possible to deprotect peptides and nucleotides on the supports: this procedure may be used for the preparation of affinity-chromatographic materials.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19840670518
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