ISSN:
1052-9306
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The products arising from the reactions of ribonuclease with glucose or fructose have been studied by means of matrix-assisted laser desorption/ionization mass spectrometry. The reactions have been carried out at physiological pH, with two different sugar concentrations and different incubation times. A maximum increase in molecular weight, corresponding to 485 Da, was found in the case of ribonuclease incubated with 0.25 M fructose for 6 days. Furthermore clear differences have been found in the reactivity of glucose and fructose; in particular, while glucose reacts faster than fructose in the early stage of the glycation, the rearrangements of the Amadori adducts are favoured using fructose as reagent sugar.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200230502
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