ISSN:
0268-2605
Keywords:
germathiazolidines
;
germadithioacetals
;
germylated oxide
;
germylated sulfide
;
N-substituted cysteamine
;
toxicity
;
radioprotective activity
;
Chemistry
;
Industrial Chemistry and Chemical Engineering
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Further to our work concerning organometallic compounds active in chemical radioprotection, we report the synthesis and pharmacological study (radioprotective activity, toxicity) of new germathiazolidines and germadithioacetals derived from cysteamine, methylcysteamine and N-substituted cysteamine. A germylated oxide and sulfide with methylcysteamine hydrochloride as ligand were also investigated.A notable decrease in the toxicity and a fairly large increase in the radioprotective activity of these new organogermylated compounds were observed compared with cysteamine, methylcysteamine and N-substituted cysteamine.
Additional Material:
10 Ill.
Type of Medium:
Electronic Resource
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