Digitale Medien
Oxford, UK
:
Blackwell Publishing Ltd
The @journal of eukaryotic microbiology
26 (1979), S. 0
ISSN:
1550-7408
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Biologie
Notizen:
The process by which malaria parasites are killed in sickled erythrocytes was studied by electron microscopy. In vitro cultures of Plasmodium falciparum in sickle cell hemoglobin (HbS) homozygous (SS) and heterozygous (SA) red cells were deoxygenated for up to 6 h and fixed under anaerobic conditions. Parasites in SS cells appeared to be disrupted by intrusions of needle-like deoxyHbS aggregates; disintegration of cytoplasm and membranes followed. In SA red cells, the parasites were generally not disrupted. Instead, extensive vacuolization occurred, a sign of metabolic inhibition. The resistance of HbS gene carriers to malaria results partly from these causes of intracellular parasite death.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1550-7408.1979.tb02760.x
Permalink
|
Standort |
Signatur |
Erwartet |
Verfügbarkeit |