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  • 1
    Electronic Resource
    Electronic Resource
    A specific point mutation in the mitochondrial genome of Caucasians with MELAS (1991)
    Springer
    Human genetics 〈Berlin〉 88 (1991), S. 233-236 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The mitochondrial DNA (mtDNA) of Japanese patients suffering from the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and strokelike episodes (MELAS) exhibits a specific heteroplasmic A→G transition in the tRNALeu at position 3243. In this study, we investigated mtDNA from skeletal muscle, cardiac muscle, brain, liver, diaphragm, fibroblasts and blood cells of four Caucasians with MELAS, one younger healthy sister of two MELAS patients, and eleven controls. We found that 1) the mutation was present in all investigated tissues of Caucasians with MELAS but not in controls, 2) within a single patient, the tissue-specific variation of the copy number of mutated mtDNA covered the same range as in the skeletal muscle of different patients, 3) the mutation was also present in the blood cells of the healthy sister of two MELAS siblings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206080
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  • 2
    Electronic Resource
    Electronic Resource
    Low-temperature iron-nitride phase transformations induced by ion bombardment (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 80 (1996), S. 3127-3129 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We show that for the Fe–N system the combined use of ion irradiation and thermal annealing can lower the temperature for a given phase transformation. By Ar bombarding N-implanted Fe samples at 250 and 300 °C, we have induced the ε-Fe2N⇒ε-Fe2+xN+ε-Fe3.2N and the ε-Fe2N⇒ε-Fe3N+γ′-Fe4N phase transformations, respectively. These temperatures are 50 °C lower than the ones needed to produce the same transformations by thermal annealing. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.363825
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  • 3
    Electronic Resource
    Electronic Resource
    Desorption measurements of copper and copper alloys for PEP-II
    Amsterdam : Elsevier
    Vacuum 44 (1993), S. 489-491 
    Details
    ISSN: 0042-207X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0042-207X(93)90079-P
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of Magnesium Deficiency on Magnesium and Calcium Content in Bone and Cartilage in Developing Rats in Correlation to Chondrotoxicity (1997)
    Springer
    Calcified tissue international 61 (1997), S. 230 -238 
    Details
    ISSN: 1432-0827
    Keywords: Key words:Magnesium — Calcium — Bone — Cartilage — Quinolones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Quinolone-induced arthropathy has been described in juvenile rats between 3 and 6 weeks of age, but not in adult rats. The mechanism of this chondrotoxic effect is probably related to the Mg2+-chelating properties of the drugs, since identical cartilage lesions were observed in magnesium-deficient juvenile rats without quinolone treatment. However, the reasons for the phase-specificity of the effect are unknown. In the present study, we fed a magnesium-deficient diet to Wistar rats at different postnatal developmental stages. Cartilage lesions were only observed in magnesium-deficient rats between 3 and 5 weeks of age, but not in rats receiving the magnesium-deficient diet during weeks 5 to 8, weeks 8 to 11, or months 15 to 16. The formation of cartilage lesions was not related to the magnesium concentration in plasma, since magnesium concentrations in plasma were similarly reduced in rats with and without cartilage lesions. However, chondrotoxicity correlated with magnesium content in articular cartilage. In articular cartilage (articular and epiphyseal cartilage in immature rats) and bone, magnesium content was more reduced in rats receiving the magnesium-deficient diet between 3 and 5 weeks of age as compared with rats receiving the magnesium-deficient diet during weeks 8 to 11 postnatally. It was not possible to reduce the magnesium content in bone tissue of 15-month-old Wistar rats, which suggests a lower magnesium turnover in aged rats. Magnesium content in epiphyseal cartilage of 2-week-old rats (total femoral head) was 41.9 ± 16.9 mmol/kg dry weight. The magnesium content in joint hyaline cartilage was significantly lower in 4-week-old rats (19.5 ± 3.6 mmol/kg dry weight) and increased subsequently again to 48.5 ± 9.2 mmol/kg dry weight (mean ± SD; n= 8 to 16). Increase of the magnesium content in femoral bone between weeks 4 and 6 postnatally was less pronounced (139 ± 10 and 175 ± 15 mmol/kg dry weight, respectively). Taken together, these data show that in 4-week-old rats, magnesium concentration in joint hyaline cartilage is significantly lower than at other times during postnatal development. Only at this developmental stage can cartilage lesions be induced by feeding rats a magnesium-deficient diet. This period correlates well with the sensitive phase of immature rats toward the chondrotoxic action of quinolones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900328
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  • 5
    Electronic Resource
    Electronic Resource
    Robust circadian rhythmicity of Drosophila melanogaster requires the presence of lateral neurons: a brain-behavioral study of disconnected mutants (1998)
    Springer
    Journal of comparative physiology 182 (1998), S. 435-453 
    Details
    ISSN: 1432-1351
    Keywords: Key words Circadian pacemakers ; Clocks ; Insects ; Locomotor activity ; Pigment-dispersing hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Mutations at the disconnected (disco) locus of Drosophila melanogaster disrupt neural cell patterning in the visual system, leading to the loss of many optic lobe neurons. Drosophila's presumptive circadian pacemaker neurons – the dorsal and ventral lateral neurons – are usually among the missing cells, and most disco flies are behaviorally arrhythmic. In this study, I show that ventral lateral neurons (LNvs) are occasionally present and provoke robust circadian rhythmicity in disco mutants. Of 357 individual disco flies four animals with robust circadian rhythmicity were found. All four retained LNvs together with terminals in the superior protocerebrum. Residual or bi-circadian rhythmicity was found in about 20% of all flies; the remaining flies were completely arrhythmic. One of the flies with residual rhythmicity and two of the arrhythmic flies also had some LNvs stained. However, these flies lacked the LNv fibers in the superior protocerebrum. The results suggest that the presence of single LNvs is sufficient to provoke robust circadian rhythmicity in locomotor activity if the LNv terminals reach the superior protocerebrum. The presence of residual or bi-circadian rhythmicity in 20% of the flies without LNvs indicates that also other cells contribute to the rhythmic control of locomotor activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003590050192
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  • 6
    Electronic Resource
    Electronic Resource
    Adaptation of the filamentous fungus Ashbya gossypii to hyperosmotic stress: different osmoresponse to NaCl and mannitol stress (1998)
    Springer
    Applied microbiology and biotechnology 50 (1998), S. 219-226 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Osmoadaption mechanisms of the biotechnologically important hemiascomycete Ashbya gossypii were investigated, thereby distinguishing between halo- and osmotolerance by exposure to NaCl and mannitol stress. We studied the growth and ultrastructure of differently treated cells and quantified the intracellular contents of compatible solutes and inorganic ions. Mannitol affected growth of A. gossypii at concentrations above 0.8 M, whereas NaCl inhibited growth at 0.2 M. NaCl-treated cells differed from control cells in having smaller vacuoles, which occupied a smaller part of the cell volume. Glycerol was found to be the predominant compatible solute in A. gossypii; accumulation of inorganic ions could not be detected. Measurement of glycerol uptake under isosmotic conditions as well as upon hyperosmotic stress revealed the existence of a highly active glycerol-uptake system, which, however, was down-regulated under hyperosmotic stress. Investigation of glycerol biosynthesis by measuring glycerol-3-phosphate dehydrogenase activity under hyperosmotic conditions indicated that accumulation of glycerol in A. gossypii is almost solely due to biosynthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530051280
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  • 7
    Electronic Resource
    Electronic Resource
    Biochemical, psychometric, and neuropsychological studies in heterozygotes for various lipidoses (1980)
    Springer
    Human genetics 〈Berlin〉 55 (1980), S. 103-110 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A sample of 38 clinically unaffected carriers for various lipidoses and their noncarrier relatives was studied with biochemical, psychological, and neuropsychological tests under blind conditions. The largest group of carriers was that for metachromatic leucodystrophy (MLD). The mean activity of arylsulphatase A or cerebroside sulphatase in the obligate carriers was 25%–30% of the control values, some heterozygotes showing little more activity than MLD patients. It was found that compared with the controls all heterozygotes (both obligate and facultative) differ unfavourably in some personality traits and in WISA subtests, including capacity for spatial cognition. These differences are especially obvious in a group of seven MLD carriers from the same family. With respect to reaction times, performance was significantly slower in MLD carriers, and particularly in those with enzyme activity lower than 30% of the control values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00329134
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of Kr post-bombardment on carbonitrides produced in a low carbon nitrogen-implanted steel (1992)
    Springer
    Applied physics 54 (1992), S. 225-232 
    Details
    ISSN: 1432-0630
    Keywords: 61.70T ; 76.80 ; 78.90
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The effects of Kr post-bombardment on carbonitrides produced by N-implantation in a low carbon steel are studied by means of conversion electron Mössbauer spectroscopy, nuclear reaction analysis and Rutherford backscattering technique. The results show two main features: dissolution and reprecipitation of the produced carbonitrides and modification of the thermal behaviour of the precipitates. Recently we have performed similar experiments bombarding samples of the same steel with He and Ar. Comparison of the experiments shows that irradiation with Ar or Kr ions provides the best retention of carbonitrides at 450° C. On the other hand irradiation with Kr ions to the same dpa level is most effective in producing the dissolution and reprecipitation process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00323841
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  • 9
    Electronic Resource
    Electronic Resource
    QCD explanation of oscillating hadron and jet multiplicity moments (2003)
    Springer
    The European physical journal 31 (2003), S. 57-71 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. Ratios of multiplicity moments, H q (cumulant over factorial moments K q /F q ), have been observed to show an oscillatory behavior with respect to order, q. Recent studies of e + e - annihilations at LEP have shown, moreover, that the amplitude and oscillation length vary strongly with the jet resolution parameter y cut. We study the predictions of the perturbative QCD parton cascade assuming low non-perturbative cut-off ( $Q_0\sim \Lambda_{\mathrm {{QCD}}}\sim $ few 100 MeV) and derive the expectations as a function of the CMS energy and jet resolution from threshold to very high energies. We consider numerical solutions of the evolution equations of gluodynamics in double logarithmic and modified leading logarithmic approximations (DLA, MLLA), as well as results from a parton MC with readjusted parameters. The main characteristics are obtained in MLLA, while a more numerically accurate description is obtained by the MC model. A unified description of correlations between hadrons and correlations between jets emerges, in particular for the transition region of small y cut.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epjc/s2003-01315-1
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  • 10
    Electronic Resource
    Electronic Resource
    Thermal behavior of bubbles and nitrides in a Cr-rich steel (1994)
    Springer
    Hyperfine interactions 83 (1994), S. 253-258 
    Details
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The evolution of the nitrides produced by N-implantation of Cr-rich steel samples previously bombarded with Kr and annealed up to temperature corresponding to 0.5 of the melting point is studied by means of conversion electron Mössbauer spectroscopy (CEMS), nuclear reaction analysis (NRA), and transmission electron microscopy (TEM) techniques. The TEM results show the size evolution of the bubbles. The dependence of the bubbles on the nitride evolution is established by CEMS results and a retention ofε-Fe2+x N up to 400°C was observed. The N-profile was obtained by NRA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02074281
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