ISSN:
0009-2940
Keywords:
2,2′-Bipyridines
;
Pyridines, optically active
;
Chiral ligands
;
Asymmetric synthesis
;
Catalysis, enantioselective
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Optically active pyridine derivatives 2, 15, 18, 19, 21, 26, and 27 are obtained by enantioselective reduction of the corresponding ketones 5, 7, 11-13, 24, and 25 using the chiral borane reagent chlorodiisopinocampheylborane [(Ipc)2BCl]. Nickel(0)-mediated coupling of bromopyridines 2, 15, and 31 gives C2-symmetric 2,2′-bipyridines (R,R)-32, (R,R′)-33, and (S,S)-38, respectively, which form metal complexes with CoII, PdII, CuI, and AgI. Aryl-substituted pyridines 26, and 39-41 are synthesized by palladium(0)-catalyzed cross couplings of 2 and 15 with boronic acids 42-44.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19921250528
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