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  • 1
    Publication Date: 1931-01-01
    Print ISSN: 0949-944X
    Electronic ISSN: 1432-041X
    Topics: Biology
    Published by Springer
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 124 (1931), S. 666-706 
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Zusammenfassung 1. Es wird die Methode einer völlig isolierten Aufzucht von Amphibiengewebe der Blastula in 0,2%iger Ringerlösung und die Möglichkeit einer verlustlosen Aufteilung auch der Anurenkeime nachgewiesen. 2. Auf dem Blastulastadium wurde explantiert und isoliert aufgezogen: Präsumptives Ektoderm-, Urwirbel-, Chorda-, Medullar-, Entoderm- und Schwanzknospenmaterial. 3. An Differenzierungen ergaben sich a) herkunftsgemäße zu Chorda, Medullarplatte, Urwirbel, Epithelien, Nierenkanälchen und Muskelfasern; b) herkunftsfremde desAmblystoma-Ektoderms zu Medullarplatte. 4. Die herkunftsgemäßen Differenzierungen zu Chorda, Ektoderm und Medullarplatte und die herkunftsfremde Differenzierung vonAmblystoma-Ektoderm zu Medullargewebe sind als unabhängige Differen-zierungen anzusehen. 5. Präsumptives Entoderm-, Schwanzknospen- und Urwirbelmaterial, rein isoliert, ergaben in diesen Versuchsserien keine typischen Organdifferenzierungen.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Pharmacy world & science 12 (1990), S. 151-153 
    ISSN: 1573-739X
    Keywords: Ascorbic acid ; Cimetidine ; Cytochrome P-450 ; Hydrocortisone ; Metabolism ; Steroid hydroxylases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A blind, parallel, prospective, clinical study was conducted to investigate the effect of ascorbic acid on human serum hydrocortisone concentrations which were decreased by the administration of cimetidine. The study population included 16 male adults scheduled for major abdominal vascular surgery. The study was conducted in surgical patients under anaesthesia, in which steroidogenesis was inhibited by cimetidine. The results showed a reduction in serum hydrocortisone concentrations in patients receiving a placebo. In patients receiving ascorbic acid, there was a significant increase in serum hydrocortisone concentration. This reflects the normal serum hydrocortisone profile for this operation and anaesthetic technique. Cimetidine can bind to cytochrome P-450 covering the active haem group, the cytochrome proves to be of vital importance for hydroxylation reactions, involved in human steroidogenesis. Serum hydrocortisone concentrations will decrease when cytochrome P-450 becomes blocked. Intravenous administration of ascorbic acid was supposed to cause relief for this decrease. The reasons are undetermined yet. This investigation proved that ascorbic acid can prevent cimetidine-induced decrease of human serum hydrocortisone concentrations.
    Type of Medium: Electronic Resource
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