ISSN:
1573-501X
Keywords:
linkers
;
N-alkylamides
;
reductive amination
;
solid-phase synthesis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The 5-(4-formyl-3,5-dimethoxyphenoxy)valeric acid (Barany)linker and its monomethoxy analog were applied to theMultipin™ method of solid phase synthesis. Acomparative assessment of reductive amination and cleavage ofthese linkers under conditions of multiple synthesis indicatedthat both were applicable to a broad range of primary aminesincluding aniline and 4-nitroaniline. Apart from the greaterlability of the dimethoxy version under TFA cleavage, there wasno observable advantage of one linker over the other within thedescribed experiment.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1009642429617
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