ISSN:
1573-4919
Keywords:
transgenic mice
;
IgH enhancer
;
SV 40 large T antigen
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract In the murine IgH gene intronic enhancer (ENHiH), two major functional domains were reported. One is the E4/octomer region and another includes the μA and μB motifs. In the human ENHiH, it was reported that the HE2, which corresponds to the murine μB, and E6 motifs play an important role in an enhancer activity and a tissue-specificity at cellular level. Here we examined thein vivo function of the E6, μA and HE2 motifs within the human ENHiH by using the transgenic mice technique. The μA and HE2 motifs together revealed almost the same enhancer function as the whole human ENHiH, but the E6 motif had lesser enhancer acitivty and tissue-specificity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00926037
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