Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
FEMS immunology and medical microbiology
23 (1999), S. 0
ISSN:
1574-695X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
The currently used tuberculosis (TB) vaccine (Bacillus Calmette-Guérin) does not consistently prevent pulmonary infection. Novel vaccine strategies require an in-depth characterization of the cellular and molecular mechanisms of antituberculous protection. This review summarizes relevant data obtained in animal models of TB infection. In mycobacterial infections, immunologically mediated protection is intrinsically associated with tissue damage in the form of granuloma formation. The implications of this finding for future vaccine design and evaluation are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1574-695X.1999.tb01234.x
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