Publication Date:
1979-11-02
Description:
Electron microscopic analysis of the DNA product synthesized by detergent-disrupted preparations of Rous sarcoma virus in vitro revealed the presence of several interesting molecular forms including covalently closed circular DNA. The identification of such circular DNA indicates that virions of retroviruses contain all the components necessary to facilitate the complete synthesis of mature forms of viral DNA and therefore provide a useful system to delineate the molecular mechanisms involved in their synthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clayman, C H -- Mosharrafa, E T -- Anderson, D L -- Feras, A J -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):582-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/91199" target="_blank"〉PubMed〈/a〉
Keywords:
Avian Sarcoma Viruses/*genetics/metabolism
;
DNA, Circular/*biosynthesis
;
DNA, Single-Stranded/*biosynthesis
;
DNA, Viral/*biosynthesis
;
Microscopy, Electron
;
Molecular Weight
;
RNA-Directed DNA Polymerase/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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