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  • 1
    Publication Date: 2010-08-14
    Description: Novae are thermonuclear explosions on a white dwarf surface fueled by mass accreted from a companion star. Current physical models posit that shocked expanding gas from the nova shell can produce x-ray emission, but emission at higher energies has not been widely expected. Here, we report the Fermi Large Area Telescope detection of variable gamma-ray emission (0.1 to 10 billion electron volts) from the recently detected optical nova of the symbiotic star V407 Cygni. We propose that the material of the nova shell interacts with the dense ambient medium of the red giant primary and that particles can be accelerated effectively to produce pi(0) decay gamma-rays from proton-proton interactions. Emission involving inverse Compton scattering of the red giant radiation is also considered and is not ruled out.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fermi-LAT Collaboration -- Abdo, A A -- Ackermann, M -- Ajello, M -- Atwood, W B -- Baldini, L -- Ballet, J -- Barbiellini, G -- Bastieri, D -- Bechtol, K -- Bellazzini, R -- Berenji, B -- Blandford, R D -- Bloom, E D -- Bonamente, E -- Borgland, A W -- Bouvier, A -- Brandt, T J -- Bregeon, J -- Brez, A -- Brigida, M -- Bruel, P -- Buehler, R -- Burnett, T H -- Buson, S -- Caliandro, G A -- Cameron, R A -- Caraveo, P A -- Carrigan, S -- Casandjian, J M -- Cecchi, C -- Celik, O -- Charles, E -- Chaty, S -- Chekhtman, A -- Cheung, C C -- Chiang, J -- Ciprini, S -- Claus, R -- Cohen-Tanugi, J -- Conrad, J -- Corbel, S -- Corbet, R -- DeCesar, M E -- den Hartog, P R -- Dermer, C D -- de Palma, F -- Digel, S W -- Donato, D -- do Couto e Silva, E -- Drell, P S -- Dubois, R -- Dubus, G -- Dumora, D -- Favuzzi, C -- Fegan, S J -- Ferrara, E C -- Fortin, P -- Frailis, M -- Fuhrmann, L -- Fukazawa, Y -- Funk, S -- Fusco, P -- Gargano, F -- Gasparrini, D -- Gehrels, N -- Germani, S -- Giglietto, N -- Giordano, F -- Giroletti, M -- Glanzman, T -- Godfrey, G -- Grenier, I A -- Grondin, M-H -- Grove, J E -- Guiriec, S -- Hadasch, D -- Harding, A K -- Hayashida, M -- Hays, E -- Healey, S E -- Hill, A B -- Horan, D -- Hughes, R E -- Itoh, R -- Jean, P -- Johannesson, G -- Johnson, A S -- Johnson, R P -- Johnson, T J -- Johnson, W N -- Kamae, T -- Katagiri, H -- Kataoka, J -- Kerr, M -- Knodlseder, J -- Koerding, E -- Kuss, M -- Lande, J -- Latronico, L -- Lee, S-H -- Lemoine-Goumard, M -- Garde, M Llena -- Longo, F -- Loparco, F -- Lott, B -- Lovellette, M N -- Lubrano, P -- Makeev, A -- Mazziotta, M N -- McConville, W -- McEnery, J E -- Mehault, J -- Michelson, P F -- Mizuno, T -- Moiseev, A A -- Monte, C -- Monzani, M E -- Morselli, A -- Moskalenko, I V -- Murgia, S -- Nakamori, T -- Naumann-Godo, M -- Nestoras, I -- Nolan, P L -- Norris, J P -- Nuss, E -- Ohno, M -- Ohsugi, T -- Okumura, A -- Omodei, N -- Orlando, E -- Ormes, J F -- Ozaki, M -- Paneque, D -- Panetta, J H -- Parent, D -- Pelassa, V -- Pepe, M -- Pesce-Rollins, M -- Piron, F -- Porter, T A -- Raino, S -- Rando, R -- Ray, P S -- Razzano, M -- Razzaque, S -- Rea, N -- Reimer, A -- Reimer, O -- Reposeur, T -- Ripken, J -- Ritz, S -- Romani, R W -- Roth, M -- Sadrozinski, H F-W -- Sander, A -- Parkinson, P M Saz -- Scargle, J D -- Schinzel, F K -- Sgro, C -- Shaw, M S -- Siskind, E J -- Smith, D A -- Smith, P D -- Sokolovsky, K V -- Spandre, G -- Spinelli, P -- Stawarz, L -- Strickman, M S -- Suson, D J -- Takahashi, H -- Takahashi, T -- Tanaka, T -- Tanaka, Y -- Thayer, J B -- Thayer, J G -- Thompson, D J -- Tibaldo, L -- Torres, D F -- Tosti, G -- Tramacere, A -- Uchiyama, Y -- Usher, T L -- Vandenbroucke, J -- Vasileiou, V -- Vilchez, N -- Vitale, V -- Waite, A P -- Wallace, E -- Wang, P -- Winer, B L -- Wolff, M T -- Wood, K S -- Yang, Z -- Ylinen, T -- Ziegler, M -- Maehara, H -- Nishiyama, K -- Kabashima, F -- Bach, U -- Bower, G C -- Falcone, A -- Forster, J R -- Henden, A -- Kawabata, K S -- Koubsky, P -- Mukai, K -- Nelson, T -- Oates, S R -- Sakimoto, K -- Sasada, M -- Shenavrin, V I -- Shore, S N -- Skinner, G K -- Sokoloski, J -- Stroh, M -- Tatarnikov, A M -- Uemura, M -- Wahlgren, G M -- Yamanaka, M -- New York, N.Y. -- Science. 2010 Aug 13;329(5993):817-21. doi: 10.1126/science.1192537.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Space Science Division, Naval Research Laboratory, Washington, DC 20375, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20705855" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2013-06-08
    Description: Repulsive guidance molecule family members (RGMs) control fundamental and diverse cellular processes, including motility and adhesion, immune cell regulation, and systemic iron metabolism. However, it is not known how RGMs initiate signaling through their common cell-surface receptor, neogenin (NEO1). Here, we present crystal structures of the NEO1 RGM-binding region and its complex with human RGMB (also called dragon). The RGMB structure reveals a previously unknown protein fold and a functionally important autocatalytic cleavage mechanism and provides a framework to explain numerous disease-linked mutations in RGMs. In the complex, two RGMB ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors in a pH-dependent manner. We demonstrate that all RGM-NEO1 complexes share this architecture, which therefore represents the core of multiple signaling pathways.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730555/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730555/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bell, Christian H -- Healey, Eleanor -- van Erp, Susan -- Bishop, Benjamin -- Tang, Chenxiang -- Gilbert, Robert J C -- Aricescu, A Radu -- Pasterkamp, R Jeroen -- Siebold, Christian -- 082301/Wellcome Trust/United Kingdom -- 083111/Wellcome Trust/United Kingdom -- 090532/Wellcome Trust/United Kingdom -- 097301/Wellcome Trust/United Kingdom -- A14414/Cancer Research UK/United Kingdom -- G0700232/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2013 Jul 5;341(6141):77-80. doi: 10.1126/science.1232322. Epub 2013 Jun 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. christian@strubi.ox.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23744777" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Biophysical Phenomena ; Cell Adhesion Molecules, Neuronal/*chemistry/genetics ; Conserved Sequence ; Crystallography, X-Ray ; Humans ; Membrane Proteins/*chemistry ; Mutation ; Oligopeptides/chemistry ; Protein Structure, Tertiary ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2018-01-25
    Description: Analysis of genetic variation can provide insights into ecological and evolutionary diversification which, for commercially harvested species, can also be relevant to the implementation of spatial management strategies and sustainability. In comparison with other marine biodiversity hot spots, there has been less genetic research on the fauna of the southwest Indian Ocean (SWIO). This is epitomized by the lack of information for lethrinid fish, which support socioeconomically important fisheries in the region. This study combines comparative phylogeographic and population genetic analyses with ecological niche modeling to investigate historical and contemporary population dynamics of two species of emperor fish ( Lethrinus mahsena and Lethrinus harak ) across the SWIO. Both species shared similarly shallow phylogeographic patterns and modeled historical (LGM) habitat occupancies. For both species, allele frequency and kinship analyses of microsatellite variation revealed highly significant structure with no clear geographical pattern and nonrandom genetic relatedness among individuals within samples. The genetic patterns for both species indicate recurrent processes within the region that prevent genetic mixing, at least on timescales of interest to fishery managers, and the potential roles of recruitment variability and population isolation are discussed in light of biological and environmental information. This consistency in both historical and recurrent population processes indicates that the use of model species may be valuable in management initiatives with finite resources to predict population structure, at least in cases wherein biogeographic and ecological differences between taxa are minimized. Paradoxically, mtDNA sequencing and microsatellite analysis of samples from the Seychelles revealed a potential cryptic species occurring in sympatry with, and seemingly morphologically identical to, L. mahsena . BLAST results point to the likely misidentification of species and incongruence between voucher specimens, DNA barcodes, and taxonomy within the group, which highlights the utility and necessity of genetic approaches to characterize baseline biodiversity in the region before such model-based methods are employed. Here we present a combined comparative phylogeographic, population genetic, and ecological niche model investigation of two emperor fish species ( Lethrinus mahsena and L. harak ) in the southwest Indian Ocean. Both species displayed consistencies in genetic patterns that highlight the potential use of model species in fisheries management; mitochondrial DNA (mtDNA) sequencing revealed shallow phylogeographic structuring, whereas microsatellite variation yielded highly significant structure with limited geographic pattern, suggesting processes that inhibit genetic mixing within the SWIO. Furthermore, mtDNA sequencing and microsatellite analysis of samples from the Seychelles revealed a potential cryptic species occurring in sympatry with, and seemingly morphologically identical to, L. mahsena .
    Electronic ISSN: 2045-7758
    Topics: Biology
    Published by Wiley
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 194 (1962), S. 395-396 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Two objections may be raised regarding experiments involving electrical stimulation and those involving estimation of co-ordinated motor activity. First, it is difficult to be certain that there is no spread of current w^hen stimulating the spinal cords of such small animals. Secondly, it is ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 55 (1999), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Young plaice, kept on a standard background and trained for 3–4 weeks, were photographed to record short-term nervously controlled responses to plain grey and patterned backgrounds, graded and quantitatively defined with regard to reflectivity and dimensions. Systems of primary, secondary and lower-order black and white spots and flecks became prominent or hidden in hierarchical order. Spots at any one level in a hierarchy were approximately evenly distributed. Black spots enlarged with increased size or number of black circles in the background but responded differently to unpatterned grey backgrounds. White spots had a centre and surrounding annulus both of which could be pale or independently variably occluded centrally, peripherally or overall. Peripheral occlusion of the annuli contributed to skin darkening and by extending inwards to include the centre it progressively diminished the white spots. The system of white spots was responsible for the smaller skin patterns, the finest being produced through disruption by the white flecks of the annuli, black spots and dark patches. There was great variation in response of individuals. Erratic and poor background responses were generally associated with abnormalities in the white spots.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of comparative physiology 27 (1940), S. 545-586 
    ISSN: 1432-1351
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung 1. Nach Unterbrechung der Farbnervenbahn durch Zerschneidung des Rückenmarks vor dem 15. Wirbel wird die Elritze zuerst tief dunkel. 2. Auf weißem Untergrund wird sie nach einigen Tagen hell. 3. Eine solche aufgehellte Elritze mit durchtrenntem Rückenmark zeigt immer noch eine Anpassung an hellen und dunklen Untergrund. 4. Das Aufhellungszentrum im Rückenmark spielt keine wesentliche Rolle bei diesem Farbwechsel. 5. Nach Durchtrennung des Sympathikus ohne Verletzung der Blutgefäße zeigt der denervierte Teil der Haut dieselben Farbreaktionen wie die ganze Haut beim Fisch mit durchtrenntem Rückenmark. 6. Einspritzungen mit Hormonen zeigen die starke Empfindlichkeit einer solchen Elritze dem unverletzten Fisch gegenüber. 7. Implantationsversuche und Einspritzungen frisch hergestellter Hypophysenextrakte von verschiedenen Tieren führten zu widersprechenden Ergebnissen. 8. Einspritzungen von Serum aus hell und dunkel angepaßten Forellen scheinen auf die Existenz eines Verdunkelungshormons bei der Forelle hinzudeuten. 9. Nach Entfernung der Hypophyse bei Elritzen mit durchschnittenem Rückenmark können die Fische im weißen Aquarium nicht mehr hell werden. 10. Nach Entfernung der Hypophyse bei der sonst normalen Elritze zeigt der Fisch nicht mehr seine normalen Farbreaktionen. Er kann auf weißem Untergrund nicht mehr die volle Helligkeit erreichen. Auf schwarzem Untergrund kann er eine tief dunkle Färbung nur für eine verhältnismäßig kurze Zeit halten. 11. Ein die Melanophoren zusammenballendes Hormon wird in der Hypophyse der Elritze abgesondert, und zwar wahrscheinlich im Vorderlappen. 12. Einige Beobachtungen deuten darauf hin, daß ein die Melanophoren ausbreitendes Hormon im Zwischenlappen der Hypophyse der Elritze abgesondert wird. Diese Beobachtungen sind aber nicht beweisend. 13. Die Elritze mit durchtrenntem Rückenmark wird von der Lichtintensität beeinflußt. Beleuchtung ruft eine Ausbreitung der Melanophoren hervor, während sie im Dunkeln mehr zusammengeballt sind. Der beschriebene Einfluß des Lichtes ist lokaler Art. 14. Versuche werden beschrieben die Anhaltspunkte geben, daß nicht nur die Melanophoren kontrahierende Nervenfasern, sondern auch expandierende Nervenfasern vorhanden sind.
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  • 7
    Publication Date: 1997-06-10
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 8
    Publication Date: 1964-02-01
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 9
    Publication Date: 1962-04-01
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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