ISSN:
1573-8221
Keywords:
rhesus sensitization
;
monoclonal anti-rhesus antibodies
;
erythrocyte clearance
;
flow cytometry
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The ability of human monoclonal IgG1 to accelerate the clearance of rhesus-positive erythrocytes in rhesus-negative volunteers does not correlate with their immunosuppressive effect. Monoclonal antibodies G-17 weakly accelerated the clearance, but decreased the incidence of sensitization, while G-7 and G-12 antobodies eliminated 80–100% erythrocytes for 7 days, and used in combination, these antibodies eliminated all erythrocytes within 3 days. G-7 antibodies stimulated immune response in all doses, while G-12 antibodies stimulated antirhesus response in a dose of 600 μg and notably decreased it in a dose of 1200–1800 μg.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02433872
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