ISSN:
1600-5759
Source:
Crystallography Journals Online : IUCR Backfile Archive 1948-2001
Topics:
Chemistry and Pharmacology
,
Geosciences
,
Physics
Notes:
Terbogrel, (E)-6-[4-(3-tert-butyl-2-cyanoguanidino)phenyl]-6-(3-pyridyl)hex-5-enoic acid, C23H27N5O2, a mixed thromboxane A2 receptor antagonist and thromboxane A2 synthase inhibitor, shows a hairpin-like conformation stabilized by an intramolecular hydrogen bond. A structural feature characteristic of the thromboxane A2 synthase inhibitor mode is observed: a distance of 8.4257 (19) Å between the pyridine N atom and the carboxyl group.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1107/S0108270100009872
Permalink