Publication Date:
2016-01-04
Description:
The conserved nature of sleep in Drosophila has allowed the fruit fly to emerge in the last decade as a powerful model organism in which to study sleep. Recent sleep studies in Drosophila have focused on the discovery and characterization of hyposomnolent mutants. One common feature of these animals is a change in sleep architecture: sleep bout count tends to be greater, and sleep bout length lower, in hyposomnolent mutants. I propose a mathematical model, produced by least-squares nonlinear regression to fit the formY=aX∧b, which can explain sleep behavior in the healthy animal as well as previously-reported changes in total sleep and sleep architecture in hyposomnolent mutants. This model, fit to sleep data, yields coefficient of determinationRsquared, which describes goodness of fit.Rsquared is lower, as compared to control, in hyposomnolent mutantsinsomniacandfumin. My findings raise the possibility that lowRsquared is a feature of all hyposomnolent mutants, not justinsomniacandfumin. If this were the case,Rsquared could emerge as a novel means by which sleep researchers might assess sleep dysfunction.
Electronic ISSN:
2167-8359
Topics:
Biology
,
Medicine
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