ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Incubation of the synthetic 18O-labelled phytyl-hydroquinone (O4-18O)-2 with the tocopherol cyclase from Anabaena variabilis KÜTZING (Cyanobacteria) in D2O furnished the doubly labelled γ-tocopherol, (2R,3S,4′R,8′R)-(1-18O,3-2H)-1. The chirality at C(3) was determined by two independent routes providing interlocking evidence that the enzyme-catalyzed ring closure proceeds by si-protonation of the double bond of 2 and concomitant re-attack of the phenolic O-atom.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19940770705
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