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  • 1
    Electronic Resource
    Electronic Resource
    Redesigning metabolic networks using mathematical programming (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 58 (1998), S. 267-271 
    Details
    ISSN: 0006-3592
    Keywords: metabolic engineering ; mathematical programming ; mixed integer nonlinear programming (MINLP) ; metabolic control analysis ; Dictyostelium discoideum ; tricarboxylic acid cycle ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The design of new generation bioprocessing plants is increasingly dependent on the design of process-compatible microorganisms. The latter, whether through genetic or physiological manipulations, can be greatly assisted by metabolic engineering. An emerging powerful tool in metabolic engineering research is computer-assisted cell design using mathematical programming. In this work, the problem of optimizing cellular metabolic networks has been formulated as a Mixed Integer Nonlinear Programming (MINLP) model. The model can assist genetic engineers to identify which cellular enzymes should be modified, and the new levels of activity required to produce an optimal network. Results are presented from the tricarboxylic acid cycle in Dictyostelium discoideum. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 58:267-271, 1998.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 2
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    An embankment failure on soft fissured clay (1986)
    Canadian Science Publishing
    Details
    Publication Date: 1986-11-01
    Description: Construction at the Genesee Power Project near Edmonton required 13 m high approach fills on soft clay for a roadway overpass structure. During construction, the north approach fill failed at a height of about 12 m. An investigation of the failure was carried out and a monitoring program instigated for further fill construction and piling for the overpass structure.The in situ mass strength of the soft clay was found to be controlled by defects such as slickensides rather than the intact strength. A translational mode of failure is considered most likely to have occurred, with computations based on c′ = 0 and [Formula: see text] determined from normally consolidated samples yielding the appropriate factors of safety to account for the failure. "Tearing" of the fill and overconsolidated crust due to the translational failure mechanism, with associated reduced average shear strengths, also occurred.Monitoring data for construction after the failure are presented and discussed. The effective stress path/yield envelope approach was used to assess the data. An empirical performance criterion for the site was developed for the overpass structure based on the observed deformation rates and computed factors of safety. Key words: embankment, stability, clay, failure, translational failure, effective stress path, fissured.
    Print ISSN: 0008-3674
    Electronic ISSN: 1208-6010
    Topics: Geosciences
    Published by Canadian Science Publishing
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