ISSN:
1600-5368
Source:
Crystallography Journals Online : IUCR Backfile Archive 1948-2001
Topics:
Chemistry and Pharmacology
,
Geosciences
,
Physics
Notes:
The metabolism of all-trans-retinoic acid is mediated by a cytochrome dependent P-450 system. The title compound, C19H14F3N4O+·Br− (R111214), is an inhibitor of P-450. The three planar ring systems, viz. the triazolyl, phenyl and quinolinone groups, are arranged in a propeller-like fashion around the central CH group. The dihedral angles formed by the triazolyl/phenyl, triazolyl/quinolinone and phenyl/quinolinone planes are 55.8 (1), 79.85 (9) and 78.49 (9)°, respectively. The N—H...O hydrogen bonds, involving the triazolium N—H group and the quinolinone O atom, link the cations into infinite chains stretching along the c axis of the crystal.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1107/S1600536801010315
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