Publication Date:
2012-09-28
Description:
Recent genome-wide association studies (GWASs) have identified 〉20 new loci associated with the susceptibility to psoriasis vulgaris (PsV) risk. We investigated the association of PsV and its main clinical subphenotypes with 32 loci having previous genome-wide evidence of association with PsV ( P 〈 5e–8) or strong GWAS evidence ( P 〈 5e–5 in discovery and P 〈 0.05 in replication sample) in a large cohort of PsV patients ( n = 2005) and controls ( n = 1497). We provide the first independent replication for COG6 ( P = 0.00079) and SERPINB8 ( P = 0.048) loci with PsV. In those patients having developed psoriatic arthritis ( n = 955), we found, for the first time, a strong association with IFIH1 ( P = 0.013). Analyses of clinically relevant PsV subtypes yielded a significant association of severity of cutaneous disease with variation at LCE3D locus ( P = 0.0005) in PsV and nail involvement with IL1RN in purely cutaneous psoriasis (PsC, P = 0.007). In an exploratory analysis of epistasis, we replicated the previously described HLA-C–ERAP1 interaction with PsC. Our findings show that common genetic variants associated with a complex phenotype like PsV influence different subphenotypes of high clinical relevance.
Print ISSN:
0964-6906
Electronic ISSN:
1460-2083
Topics:
Biology
,
Medicine
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