Publication Date:
2013-01-01
Description:
Two conformational polymorphs of novel 2-[2-(3-cyano-4,6-dimethyl-2-oxo-2H-pyridin-1-yl)-ethoxy]-4,6-dimethyl nicotinonitrile have been developed. The crystal structure of both polymorphs (1aand1b) seems to be stabilized by weak interactions. A difference was observed in the packing of both polymorphs. Polymorph1bhas a better binding affinity with the cyclooxygenase (COX-2) receptor than the standard (Nimesulide).
Print ISSN:
2356-6140
Electronic ISSN:
1537-744X
Topics:
Natural Sciences in General
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