Publication Date:
2011-07-20
Description:
In PNAS, Hsu et al. (1) observed an early transient increase (here, termed a blip) in hepatitis C virus (HCV) viral load in 92 out of 145 Taiwanese patients with chronic hepatitis C treated with pegylated IFN-α (IFN) and ribavirin and found that these blips were significantly associated with the outcome of therapy [i.e., sustained virologic response (SVR)]. Further, they sought to explain the origin and time of these blips using a version of a well-studied mathematical model of HCV infection and treatment (2) in a nonstandard way. Although these blips are interesting, several concerns need to be raised before...
Keywords:
Letters
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
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