Publication Date:
2006-04-29
Description:
Wnt proteins function as morphogens that can form long-range concentration gradients to pattern developing tissues. Here, we show that the retromer, a multiprotein complex involved in intracellular protein trafficking, is required for long-range signaling of the Caenorhabditis elegans Wnt ortholog EGL-20. The retromer functions in EGL-20-producing cells to allow the formation of an EGL-20 gradient along the anteroposterior axis. This function is evolutionarily conserved, because Wnt target gene expression is also impaired in the absence of the retromer complex in vertebrates. These results demonstrate that the ability of Wnt to regulate long-range patterning events is dependent on a critical and conserved function of the retromer complex within Wnt-producing cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coudreuse, Damien Y M -- Roel, Giulietta -- Betist, Marco C -- Destree, Olivier -- Korswagen, Hendrik C -- New York, N.Y. -- Science. 2006 May 12;312(5775):921-4. Epub 2006 Apr 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Hubrecht Laboratory and Center for Biomedical Genetics, Uppsalalaan 8, 3584 CT, Utrecht, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16645052" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Body Patterning
;
Caenorhabditis elegans/cytology/genetics/growth & development/*physiology
;
Caenorhabditis elegans Proteins/analysis/genetics/*physiology
;
Cell Line
;
Gene Expression
;
Glycoproteins/analysis/genetics/*physiology
;
Humans
;
Multiprotein Complexes/*physiology
;
Mutation
;
Neurons/cytology/physiology
;
RNA Interference
;
*Signal Transduction
;
Transgenes
;
Vesicular Transport Proteins/genetics/physiology
;
Wnt Proteins/*physiology
;
Xenopus
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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