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  • 1
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    Effects of the obese gene product on body weight regulation in ob/ob mice (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-07-28
    Description: C57BL/6J mice with a mutation in the obese (ob) gene are obese, diabetic, and exhibit reduced activity, metabolism, and body temperature. Daily intraperitoneal injection of these mice with recombinant OB protein lowered their body weight, percent body fat, food intake, and serum concentrations of glucose and insulin. In addition, metabolic rate, body temperature, and activity levels were increased by this treatment. None of these parameters was altered beyond the level observed in lean controls, suggesting that the OB protein normalized the metabolic status of the ob/ob mice. Lean animals injected with OB protein maintained a smaller weight loss throughout the 28-day study and showed no changes in any of the metabolic parameters. These data suggest that the OB protein regulates body weight and fat deposition through effects on metabolism and appetite.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pelleymounter, M A -- Cullen, M J -- Baker, M B -- Hecht, R -- Winters, D -- Boone, T -- Collins, F -- New York, N.Y. -- Science. 1995 Jul 28;269(5223):540-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Amgen, Inc., Thousand Oaks, CA 91320, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7624776" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/drug effects ; Analysis of Variance ; Animals ; Blood Glucose/analysis ; Body Composition/drug effects ; Body Temperature/drug effects ; Dose-Response Relationship, Drug ; Drinking/drug effects ; Eating/*drug effects ; Energy Metabolism/drug effects ; Female ; Insulin/blood ; Leptin ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Motor Activity/drug effects ; Obesity/genetics/*physiopathology ; Oxygen Consumption/drug effects ; Proteins/genetics/*pharmacology ; Recombinant Proteins/pharmacology ; Weight Loss/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Paradoxical false memory for objects after brain damage (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-12-04
    Description: Poor memory after brain damage is usually considered to be a result of information being lost or rendered inaccessible. It is assumed that such memory impairment must be due to the incorrect interpretation of previously encountered information as being novel. In object recognition memory experiments with rats, we found that memory impairment can take the opposite form: a tendency to treat novel experiences as familiar. This impairment could be rescued with the use of a visual-restriction procedure that reduces interference. Such a pattern of data can be explained in terms of a recent representational-hierarchical view of cognition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McTighe, Stephanie M -- Cowell, Rosemary A -- Winters, Boyer D -- Bussey, Timothy J -- Saksida, Lisa M -- Biotechnology and Biological Sciences Research Council/United Kingdom -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2010 Dec 3;330(6009):1408-10. doi: 10.1126/science.1194780.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21127256" target="_blank"〉PubMed〈/a〉
    Keywords: Amnesia/physiopathology ; Animals ; Brain Injuries/*physiopathology ; Brain Mapping ; Cognition ; Darkness ; Male ; *Memory ; Memory Disorders/*physiopathology ; Models, Neurological ; Neural Pathways/physiology ; Random Allocation ; Rats ; *Recognition (Psychology) ; Sensory Deprivation ; Temporal Lobe/*injuries/*physiopathology ; Vision, Ocular
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Break-induced telomere synthesis underlies alternative telomere maintenance (2016)
    Springer Nature
    In: Nature
    Details
    Publication Date: 2016-11-03
    Description: Break-induced telomere synthesis underlies alternative telomere maintenance Nature 539, 7627 (2016). doi:10.1038/nature20099 Authors: Robert L. Dilley, Priyanka Verma, Nam Woo Cho, Harrison D. Winters, Anne R. Wondisford & Roger A. Greenberg Homology-directed DNA repair is essential for genome maintenance through templated DNA synthesis. Alternative lengthening of telomeres (ALT) necessitates homology-directed DNA repair to maintain telomeres in about 10–15% of human cancers. How DNA damage induces assembly and execution of a DNA replication complex (break-induced replisome) at
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 4
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    Tracking icebergs with time-lapse photography and sparse optical flow, LeConte Bay, Alaska, 2016–2017 (2019)
    Cambridge University Press
    Details
    Publication Date: 2019
    Description: 〈div data-abstract-type="normal"〉〈p〉We present a workflow to track icebergs in proglacial fjords using oblique time-lapse photos and the Lucas-Kanade optical flow algorithm. We employ the workflow at LeConte Bay, Alaska, where we ran five time-lapse cameras between April 2016 and September 2017, capturing more than 400 000 photos at frame rates of 0.5–4.0 min〈span〉−1〈/span〉. Hourly to daily average velocity fields in map coordinates illustrate dynamic currents in the bay, with dominant downfjord velocities (exceeding 0.5 m s〈span〉−1〈/span〉 intermittently) and several eddies. Comparisons with simultaneous Acoustic Doppler Current Profiler (ADCP) measurements yield best agreement for the uppermost ADCP levels (~ 12 m and above), in line with prevalent small icebergs that trace near-surface currents. Tracking results from multiple cameras compare favorably, although cameras with lower frame rates (0.5 min〈span〉−1〈/span〉) tend to underestimate high flow speeds. Tests to determine requisite temporal and spatial image resolution confirm the importance of high image frame rates, while spatial resolution is of secondary importance. Application of our procedure to other fjords will be successful if iceberg concentrations are high enough and if the camera frame rates are sufficiently rapid (at least 1 min〈span〉−1〈/span〉 for conditions similar to LeConte Bay).〈/p〉〈/div〉
    Print ISSN: 0022-1430
    Electronic ISSN: 1727-5652
    Topics: Geography , Geosciences
    Published by Cambridge University Press on behalf of The International Glaciological Society (IGS).
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  • 5
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    Meltwater intrusions reveal mechanisms for rapid submarine melt at a tidewater glacier (2019)
    Wiley
    Details
    Publication Date: 2019
    Description: Abstract Submarine melting has been implicated as a driver of glacier retreat and sea level rise, but to date melting has been difficult to observe and quantify. As a result, melt rates have been estimated from parameterizations that are largely unconstrained by observations, particularly at the near‐vertical termini of tidewater glaciers. With standard coefficients, these melt parameterizations predict that ambient melting (the melt away from subglacial discharge outlets) is negligible compared to discharge‐driven melting for typical tidewater glaciers. Here, we present new data from LeConte Glacier, Alaska that challenges this paradigm. Using autonomous kayaks, we observe ambient meltwater intrusions that are ubiquitous within 400 m of the terminus, and we provide the first characterization of their properties, structure, and distribution. Our results suggest that ambient melt rates are substantially higher ($\x100$) than standard theory predicts and that ambient melting is a significant part of the total submarine melt flux. We explore modifications to the prevalent melt parameterization to provide a path forward for improved modeling of ocean‐glacier interactions.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 6
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    Observations and Modeling of a Tidal Inlet Dye Tracer Plume (2016)
    Wiley
    Details
    Publication Date: 2016-10-05
    Description: A 9 km-long tracer plume was created by continuously releasing Rhodamine WT dye for 2.2 h during ebb tide within the southern edge of the main tidal channel at New River Inlet, NC on May 7, 2012, with highly obliquely incident waves and alongshore winds. Over 6 h from release, COAWST (coupled ROMS and SWAN, including wave, wind, and tidal forcing) modeled dye compares well with (aerial hyperspectral and in situ) observed dye concentration. Dye first was transported rapidly seaward along the main channel and partially advected across the ebb-tidal shoal until reaching the offshore edge of the shoal. Dye did not eject offshore in an ebb-tidal jet because the obliquely incident breaking waves retarded the inlet-mouth ebb-tidal flow and forced currents along the ebb shoal. The dye plume largely was confined to 〈 4 m depth. Dye was then transported downcoast in the narrow (few 100 m wide) surfzone of the beach bordering the inlet at 0.3 ms -1 driven by wave breaking. Over 6 h, the dye plume is not significantly affected by buoyancy. Observed dye mass balances close indicating all released dye is accounted for. Modeled and observed dye behavior are qualitatively similar. The model simulates well the evolution of the dye center of mass, lateral spreading, surface area, and maximum concentration, as well as regional (“inlet” and “ocean”) dye mass balances. This indicates that the model represents well the dynamics of the ebb-tidal dye plume. Details of the dye transport pathways across the ebb shoal are modeled poorly perhaps owing to low-resolution and smoothed model bathymetry. Wave forcing effects have a large impact on the dye transport. This article is protected by copyright. All rights reserved.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 7
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    Dynamic remodeling of a basolateral-to-central amygdala glutamatergic circuit across fear states (2019)
    Springer Nature
    Details
    Publication Date: 2019
    Print ISSN: 1097-6256
    Electronic ISSN: 1546-1726
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 8
    Electronic Resource
    Electronic Resource
    Phytic Acid Content of Crude, Degummed and Retail Soybean Oils and Its Effect on Stability (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 49 (1984), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An anion exchange method was employed to determine phytate content of industrial crude and degummed soybean oil and soybean oil purchased at retail. The phytate content of crude oil ranged from 48.9–339.4 ppm and degummed oil ranged from 3.9–50.9 ppm phytate. Degumming removed from 16.1–97.1% of the phytate. Retail oil did not contain detectable amounts of phytate. Peroxide values were measured to test the effect of added phytate on the stability of oil exposed to heat, light and copper. In these tests phytate did not affect oil stability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1984.tb10406.x
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  • 9
    Electronic Resource
    Electronic Resource
    Behavior of Phospholipids in Soybean Oil on Silicic Acid (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 49 (1984), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The unexpected recovery of soybean oil phospholipids in the non-polar eluents from a silicic acid column led to this investigation. Crude soybean oil dissolved in ethyl ether was mixed with silicic acid, filtered and the amount of phosphorus determined in the filtrate. Increasing time of contact with silicic acid, and pretreatment by heat or sonication decreased the amount of phosphorus in the filtrate. These findings indicate that phospholipids in crude soybean oil occur in a form that gives them a nonpolar character that can be changed. However, a certain portion of the phospholipids are not changed by the treatments described. These results are compared to phosphorus loss by degumming of soybean oil.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1984.tb15002.x
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  • 10
    Electronic Resource
    Electronic Resource
    An Improved Colorimetric Assay for Bacterial Lipase in Nonfat Dry Milk (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 54 (1989), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A modification of McKellar and Cholette's (1986) colorimetric method for determining lipase activity in reconstituted non-fat dry milk was developed. The method uses the color reaction between Fast Blue BB and the β-naphthol (BN) enzymatically cleaved from β-naphthyl cap-rylate (BNC) as a measure of lipase activity. In the modified method, a solvent system is used to clarify the sample rather than extracting the colored product. This modification allows measurement of total sample lipase by excluding centrifugation. In addition, the modified method has greater sensitivity with equal ease of use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1989.tb05159.x
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